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Details for receptor: angiotensin receptor 2

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EndoNet ID: ENR00777

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Synonyms

  • AT2
  • angiotensin II type 2 receptor
  • AGTR2
  • angiotensin receptor 2

General information

  • Angiotensin II type 2 receptor is involved in apoptosis. [1]
  • The AT2 receptor is ubiquitously expressed at high levels in developing fetal tissues, but its expression rapidly decreases after birth and is limited to the vasculature, adipose tissue, pancreas, heart, adrenal gland, uterus, ovary and certain brain nuclei of adult mammals. [2]
  • The AT2 receptor is a seven-domain transmembrane receptor coupled to an inhibitory G protein. [2]
  • The AT2 receptors may antagonize the actions of the AT1 receptor by inducing vasodilatation and programmed cell death, and by inhibiting cell growth and proliferation. [2]

Links to other resources

UniProt P50052
Ensembl ENST00000371906

Binding hormones

  • angiotensin II
    • XN000004854

Anatomical structures with this receptor

  • circulatory_system__hematopoietic_system

  • adipose_tissue

    Influences

    • positive NO
      • Activation of AT2 results in the production of NO and activation of several phosphatases, such as PTPase and PP2A, resulting in the inactivation of MAPK and changes in potassium and calcium current. [2]

  • pancreas

  • heart

    Induced phenotypes

    • cell growth
      • Angiotensin 2 binding sites have been identified in the human heart and AT2 receptor may be involved in cell growth and proliferation. [3]

  • adrenal_gland

  • uterus

  • ovary

  • lipocyte_of_liver

    Induced phenotypes

    • regulation of tissue remodeling
      • The renin-angiotensin system plays an important role in hepatic fibrogenesis. After activation, human hepatic stellate cells express the components of the renin-angiotensin system and synthesize angiotensin II,which lead to the suggestions that locally generated angiotensin II could participate in tissue remodeling in the human liver. [4]

  • hepatocyte

  • kidney

  • proximal_tubule_of_nephron

Reference