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Details for receptor: CCK-1

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EndoNet ID: ENR00780

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Synonyms

  • CCK-1
  • cholecystokinin receptor 1
  • CCK1
  • cholecystokinin type A receptor
  • CCK-A

General information

  • 1000-fold higher affinity for CCK rather than for gastrin.
  • individual chief cells, mucous neck cells and parietal cells (12.3 +/- 4.7%) expressed CCK-A receptors. [1]
  • In fundic mucosa, CCK-A receptor mRNA and protein mapped to D cells (37.4 +/-7.7). [1]

Links to other resources

UniProt P32238
Ensembl ENST00000295589

Binding hormones

  • cholecystokinin
    • Binding to CCK-A receptors stimulates amylase release from the pancreas.
  • gastrin
  • cholecystokinin 58
    • CCK-58 and CCK-8 stimulate the CCK1 receptor with a similar efficacy. [2]
  • cholecystokinin 8
    • CCK-58 and CCK-8 stimulate the CCK1 receptor with a similar efficacy. [2]
  • cholecystokinin 39
    • CCK is found as variable length linear peptides, including 58, 39, 33 and eight residues, all of which share the pharmacophoric domain for the CCK1 receptor. [3]

Anatomical structures with this receptor

  • cell_of_adrenal_gland_zona_glomerulosa

    Influences

    • positive aldosterone
      • Rat adrenal zona glomerulosa expresses CCK1-R and CCK2-R and is provided with CCK-binding sites, whose activation enhances aldosterone secretion. Cholecystokinin, acting through these cholecystokinin receptors 1 and 2 coupled with the adenylate cyclase/PKA cascade, exerts a sizeable secretagogue action on rat zona glomerulosa cells. [4]

  • oxyntic_cell_of_gastric_gland

  • zymogenic_cell_of_gastric_gland

  • pancreas

    Influences

    • positive pancreatic alpha-amylase
      • Binding of CCk to CCK-A receptors stimulates amylase release from the pancreas.

    Induced phenotypes

    • mitogen activity
      • The gastrointestinal peptide hormone Cholecystokinin functions as major physiological pancreatic secretagogue and pancreatic acinar cell mitogen. [5]
    • positive regulation of pancreatic juice secretion
      • In humans strong evidence suggests CCK1R activation is involved in the regulation of numerous physiological processes, including stimulation of pancreatic secretion. [6]

  • hypothalamus

    Induced phenotypes

    • negative regulation of appetite
      • Cholecystokinin is released by the gastrointestinal system during meals and induces an anorexigenic response. [7]
      • This physiological pathway is believed to be an essential component of postprandial satiety. [8]
      • CCK activates POMC cells in the nucleus of the solitary tract (NTS), which is located in the brainstem. This effect of peripheral CCK is dependent upon melanocortin signaling, because in the absence of MC4R or by pharmacological inhibition of MC4R in the NTS, the anorexigenic effects of CCK are blocked. [9]

  • mucosa_of_small_intestine

    • The human CCKR1 is expressed at Protein level in the mucosa of the stomach. [10]

  • gallbladder

    Induced phenotypes

    • gastro-intestinal system smooth muscle contraction
      • In human gallbladder the CCK-induced contraction of the smooth muscle is mediate through the CCK1 receptor. [11]
      • In humans strong evidence suggests CCK1R activation is involved in the regulation of numerous physiological processes, including gallbladder contraction. [6]
    • The human CCKR1 is expressed at Protein level in the smooth muscle cells of the gallbladder. [12]

  • intestinal_smooth_muscle_cell

    Induced phenotypes

    • induction of smooth muscle contraction
      • In the human colon, the CCK-induced contraction of the smooth muscle is mediated through the CCK1 receptor. [11]
    • The human CCKR1 is expressed at Protein level in the smooth muscle cells of the intestine. [10]

  • stomach

    Induced phenotypes

    • inhibition of gastric emptying
      • In humans strong evidence suggests CCK1R activation is involved in the regulation of numerous physiological processes, including inhibition of gastric emptying. [13]

  • colon

    Induced phenotypes

    • induction of smooth muscle contraction
      • In the human colon, the CCK-induced contraction of the smooth muscle is mediated through the CCK1 receptor. [11]

  • D_cell

    Influences

    • positive somatostatin
      • The CCK1 receptor mRNA and protein have been localized in the human gastric mucosa within D cells, where CCK can stimulate somatostatin secretion. [3]
    • The CCK1 receptor mRNA and protein have been localized in the human gastric mucosa within D cells. [3]
Reference