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Details for receptor: dopamine receptor D1

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EndoNet ID: ENR00784

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Synonyms

  • D1
  • dopamine D1A receptor
  • dopamine receptor D1

General information

  • Stimulatory, acts through G-proteins; activate adenylate cyclase. [1]
  • Both D1(including the D1 and D5)- and D2(including the D2,D3 and D4 receptor)-like receptors have been reported to be expressed in the adrenal medulla, where they modulate catecholamine release. [2]

Links to other resources

UniProt P21728
Ensembl ENST00000393752

Binding hormones

  • dopamine

Anatomical structures with this receptor

  • kidney

  • adrenal_medulla

  • cell_of_adrenal_gland_zona_glomerulosa

    Influences

    • negative aldosterone
      • Dopmaine has an inhibitory effect on aldosterone secretion. Type 1 dopamine receptor has been demonstrated in the adrenal glomerulosa. [3]

  • hippocampus

    Influences

    • positive acetylcholine
      • The hippocampal ACh release is facilitated by the local stimulation of D1 receptors. [4]
Reference