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Details for receptor: ETA-R

EndoNet ID: ENR00785

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  • ETA
  • endothelin A receptor
  • endothelin-1 receptor
  • hET-AR
  • ET-A
  • ETA-R

General information

  • Stellate cells express both ETA and ETB receptors. [1]
  • The primary response mediated by the ETA receptor is vasoconstriction. [1]
  • ETA receptors are found predominantly on vascular smooth muscle cells and bind ET-1>ET-2>>>ET-3. [1]

Links to other resources

UniProt P25101
Ensembl ENST00000394047

Binding hormones

  • endothelin-1
    • The affinity of ET-1 for the ETA receptor is more than 100-fold that of ET-3. [1]
  • endothelin-2
  • endothelin-3

Anatomical structures with this receptor

  • lipocyte_of_liver

    Induced phenotypes

    • actin-mediated cell contraction
      • Interactions between endothelin-1 and hepatic stellate cells induces contractility of stellate cells from normal and cirrhotic rat liver. [2]
      • Endothelin-A and endothelin-B receptor antagonist reduces portal pressure in portal hypertensive animals, consistent with its inhibitory effect on stellate cell contraction. [2]
      • Stellate cell contractility increases with progressive liver injury and is proportional to the degree of stellate cell activation, becoming most prominent in the cirrhotic liver. Endothelin-stimulated contraction of stellate cells in cirrhotic liver may contribute to increased intrahepatic resistance and portal pressure. [2]
  • chief_cell_of_parathyroid_gland


    • negative PTH
      • ET-1 dose-dependently (10e-10 -10e-7 M) inhibited basal PTH secretion by dispersed parathyroid adenoma cells. [3]
      • ET-1 displays an in vitro inhibitory effect on basal PTH secretion and also counteracts PTH hypersecretion stimulated by low calcium. [4]