Status
Please wait ...

Details for receptor: ETB-R

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00786

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • ETB
  • endothelin B receptor
  • endothelin receptor Non-selective type
  • EDNRB
  • ETRB
  • ETB-R

General information

  • Responses depending in part on cell type: Binding of endothelins to ETB receptors on endothelial cells results in NO release and relaxation of vascular smooth muscle, whereas, on smooth muscle cells, endothelins may induce vasoconstriction. [1]
  • ETB receptors are widely distributed and have similar affinity for ET-1, ET-2, and ET-3. [1]
  • ETB receptor mRNA was intensely expressed in Bergmann glial cells. [2]

Links to other resources

UniProt P24530
Ensembl ENST00000446573

Subunit information

Sequence 
EERGFPPDR ATPLLQTAE IMTPPTKTL 
WPKGSNASL ARSLAPAEV PKGDRTAGS 
PPRTISPPP CQGPIEIKE TFKYINTVV 
SCLVFVLGI IGNSTLLRI IYKNKCMRN 
GPNILIASL ALGDLLHIV IDIPINVYK 
LLAEDWPFG AEMCKLVPF IQKASVGIT 
VLSLCALSI DRYRAVASW SRIKGIGVP 
KWTAVEIVL IWVVSVVLA VPEAIGFDI 
ITMDYKGSY LRICLLHPV QKTAFMQFY 
KTAKDWWLF SFYFCLPLA ITAFFYTLM 
TCEMLRKKS GMQIALNDH LKQRREVAK 
TVFCLVLVF ALCWLPLHL SRILKLTLY 
NQNDPNRCE LLSFLLVLD YIGINMASL 
NSCINPIAL YLVSKRFKN CFKSCLCCW 
CQSFEEKQS LEEKQSCLK FKANDHGYD 
NFRSSNKYS SS

Binding hormones

  • endothelin-1
    • When ET-1 is perfused into the liver, its localization is consistent with binding to stellate cells. [1]
  • endothelin-2
  • endothelin-3

Anatomical structures with this receptor

  • lipocyte_of_liver

    Induced phenotypes

    • actin-mediated cell contraction
      • Interactions between endothelin-1 and hepatic stellate cells induces contractility of stellate cells from normal and cirrhotic rat liver. [3]
      • Endothelin-A and endothelin-B receptor antagonist reduces portal pressure in portal hypertensive animals, consistent with its inhibitory effect on stellate cell contraction. [3]
      • Stellate cell contractility increases with progressive liver injury and is proportional to the degree of stellate cell activation, becoming most prominent in the cirrhotic liver. Endothelin-stimulated contraction of stellate cells in cirrhotic liver may contribute to increased intrahepatic resistance and portal pressure. [3]

  • chief_cell_of_parathyroid_gland

    Influences

    • negative PTH
      • Higher concentrations (10e-8 - 10e-7 M) of ET-3 were required to inhibit PTH secretion. These data are consistent with the less predominant expression of ETB receptor subtype in the adenomatous tissue. [4]

  • bergmann_glia

Reference