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Details for receptor: LHCGR-1

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  • General information
  • Subunits
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  • General information
  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00789

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Synonyms

  • LH-R
  • LHCGR-1
  • luteinizing hormone receptor
  • choriogonadotropin receptor
  • hCGR

General information

  • Receptor mediates its activity through G proteins.
  • Several constitutively activating mutations have been demonstrated in the sixth transmembrane helix of the human LH receptor (hLHR) in boys with gonadotropin-independent precocious puberty. [1]
  • Homozygous Mutation in the Luteinizing Hormone Receptor Causes Partial Leydig Cell Hypoplasia. [2]

Links to other resources

UniProt P22888
Ensembl ENST00000428232

Subunit information

Isoform Long

Sequence 
EALCPEPCN CVPDGALRC PGPTAGLTR 
LSLAYLPVK VIPSQAFRG LNEVIKIEI 
SQIDSLERI EANAFDNLL NLSEILIQN 
TKNLRYIEP GAFINLPRL KYLSICNTG 
IRKFPDVTK VFSSESNFI LEICDNLHI 
TTIPGNAFQ GMNNESVTL KLYGNGFEE 
VQSHAFNGT TLTSLELKE NVHLEKMHN 
GAFRGATGP KTLDISSTK LQALPSYGL 
ESIQRLIAT SSYSLKKLP SRETFVNLL 
EATLTYPSH CCAFRNLPT KEQNFSHSI 
SENFSKQCE STVRKVSNK TLYSSMLAE 
SELSGWDYE YGFCLPKTP RCAPEPDAF 
NPCEDIMGY DFLRVLIWL INILAIMGN 
MTVLFVLLT SRYKLTVPR FLMCNLSFA 
DFCMGLYLL LIASVDSQT KGQYYNHAI 
DWQTGSGCS TAGFFTVFA SELSVYTLT 
VITLERWHT ITYAIHLDQ KLRLRHAIL 
IMLGGWLFS SLIAMLPLV GVSNYMKVS 
ICFPMDVET TLSQVYILT ILILNVVAF 
FIICACYIK IYFAVRNPE LMATNKDTK 
IAKKMAILI FTDFTCMAP ISFFAISAA 
FKVPLITVT NSKVLLVLF YPINSCANP 
FLYAIFTKT FQRDFFLLL SKFGCCKRR 
AELYRRKDF SAYTSNCKN GFTGSNKPS 
QSTLKLSTL HCQGTALLD KTRYTEC
UniProt P22888-1

Binding hormones

  • hCG
  • LH

Anatomical structures with this receptor

  • Leydig_cell_of_testis

    Influences

    • positive testosterone
      • Luteinizing hormone secretion from pituitary and subsequent activation of Luteinizing hormone receptor in Leydig cells at the onset of puberty promotes testosterone synthesis, required for secondary sexual characteristics in males. [3]

  • theca_cell

    Influences

    • positive androstenedione
      • androstenedione is released into the blood by theca cells to provide androstenedione substrate for estrogen production in granulosa cells
    • positive testosterone

  • cell_of_adrenal_gland_zona_glomerulosa

    Influences

    • progesterone

  • granulosa_cell

    Influences

    • negative progesterone
      • Progesterone secretion was enhanced by all agents that caused down-regulationo f the LH receptor; however, there was little correlation between progesterone secretion and down-regulation [4]
    • positive estrogen
      • In females, luteinizing hormone receptor activation is required for estrogen synthesis , and LH surge from the pituitary triggers ovulation and luteinization of granulosa cell to form corpus luteum. [5]

    Induced phenotypes

    • regulation of ovulation
      • Luteinizing hormone is important for progesterone and prostaglandin secretion and ovulation. [4]
Reference