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Details for receptor: 5-HT-2A

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EndoNet ID: ENR00795

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Synonyms

  • 5-hydroxytryptamine receptor 2A
  • serotonin receptor 2A
  • 5-HT-2A

General information

  • 5-HT2A and 5-HT-2B receptor subtypes mediate liver regeneration. [1]

Links to other resources

UniProt P28223
Ensembl ENST00000378688

Binding hormones

  • serotonin

Anatomical structures with this receptor

  • pyramidal_layer_of_hippocampus

  • hippocampus

  • muscularis_of_bronchus

    Induced phenotypes

    • smooth muscle contraction
      • The 5-HT 2A receptors occur peripherally on vascular smooth muscle tissue and their function is broncho-constriction. [2]

  • smooth_muscle_cell

    Induced phenotypes

    • vasoconstriction
      • The 5-HT 2A receptors occur peripherally on vascular smooth muscle tissue and their function is vaso-constriction. [2]

  • platelet

    Induced phenotypes

    • platelet aggregation
      • The 5-HT 2A receptors occur peripherally on platelets and their function is platelet aggregation. [2]
      • Inhibiton of platelet aggregation by 5-HT 2 receptor blocking. [3]
    • regulation of serum calcium levels
      • Agonist binding to 5-HT 2A receptor activates the IP3 second messenger system and leads to the mobilization of cytosolic calcium. [4]

  • isocortex

  • liver

  • liver

    Induced phenotypes

    • liver regeneration
      • 5-HT receptor subtype 2A mediates serotonin-dependent liver regeneration. [1]

  • frontal_lobe

    Influences

    • positive acetylcholine
      • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [5]
Reference