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Details for receptor: 5-HT-2B

EndoNet ID: ENR00796

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  • 5-hydroxytryptamine receptor 2B
  • serotonin receptor 2B
  • 5-HT-2B

General information

Links to other resources

UniProt P41595
Ensembl ENST00000258400

Binding hormones

  • serotonin

Anatomical structures with this receptor

  • vascularendothelial_cell

    Induced phenotypes

    • carcinoid syndrome
      • Carcinoid tumors are characterized by their production of hormonal substances such as 5-hydroxytryptamine. The pathogenesis of the cardiac lesions and the bronchoconstriction is unknown, but the former probably involves activation of serotonin 5-HT2B receptors by serotonin. [1]
  • heart

    Induced phenotypes

    • negative regulation of apoptosis
      • Serotonin via the 5-HT2B-receptor protects cardiomyocytes against serum deprivation-induced apoptosis. [2]
      • 5-HT-2B signaling regulate mitochondrial function and structure thereby controlling apoptosis and myofibrillas organisation in the heart. [2]
    • Binding of serotonin to 5-HT-2B acitvates PI3K/Akt and ERK kinases in cardiomyocytes to protect mitochondrial damage thereby preventing apoptosis. [2]
  • muscularis_of_bronchus

  • stomach

    Induced phenotypes

    • gastro-intestinal system smooth muscle contraction
      • 5-HT 2B receptors are found peripherally in the stomach fundus and contraction of the rat stomach fundus via these receptors has been elicited. [3]
  • liver

    Induced phenotypes

    • liver regeneration
      • 5-HT receptor subtype 2B mediates serotonin-dependent liver regeneration. [4]
  • kidney

    Induced phenotypes

    • renal system process involved in regulation of blood volume
      • Central 5-HT2B receptors may play a selective role in the control of sympathetic supply to the kidney, which could be important in the central mechanisms involved in blood volume regulation. [5]
      • Activation of 5-HT-2B receptor subtypes mediate renal sympathoexcitation and hypotension. [5]
  • frontal_lobe


    • positive acetylcholine
      • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [6]