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Details for receptor: 5-HT-2C

EndoNet ID: ENR00797

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  • serotonin receptor 2C
  • 5HT-1C
  • 5-hydroxytryptamine receptor 2C
  • 5-HT-2C

General information

Links to other resources

UniProt P28335
Ensembl ENST00000371951

Binding hormones

  • serotonin

Anatomical structures with this receptor

  • hippocampus

  • substantia_nigra


    • positive GABA
      • The selective activation of 5-HT2C receptors stimulates non-DA neurons in the substantia nigra pars reticulata (SNr) and mediate an increase in GABA extracellular levels in the SNr. [1]
    • The location of 5-HT-2C recpetors is on postsynaptic sites of the substantia nigra. [2]
  • cerebral_cortex

  • corpus_striatum


    • dopamine
      • Stimulate 5-HT-2C receptors localized within the striatum have an inhibitory controll of the dopamine release in the nitrostriatal pathway. [3]
  • frontal_lobe


    • positive acetylcholine
      • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [4]