Status
Please wait ...

Details for receptor: alpha 1B-adrenoreceptor

  • Top
  • General information
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00800

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • alpha1B-AR
  • alpha-1B adrenergic receptor
  • alpha 1B-adrenoreceptor

General information

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [1]
  • Binding profiles of antagonists revealed that human prostate predominantly expressed alpha 1A-AR, whereas human aorta expressed alpha 1B-AR mainly. [2]
  • The cerebellar cortex expresses mRNA encoding all six alpha adrenergic receptor subtypes (1a, 1b, 1d, 2a, 2b, 2c), whereas dentate nucleus neurons express all subtype mRNAs, except alpha2a adrenergic receptor mRNA. [3]

Links to other resources

UniProt P35368
Ensembl ENST00000306675

Binding hormones

    Anatomical structures with this receptor

    • aorta

    • cerebellar_cortex

    • dentate_nucleus

    • Purkinje_cell

      Induced phenotypes

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 1B ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells. [3]

    • cerebellar_cortex

      Induced phenotypes

      • negative regulation of synaptic transmission, GABAergic
        • Inner stellate cells express moderate levels of alpha 1b AR mRNA. Excitation of stellate cells though parallel fibers produces GABAergic inhibition of Purkinje cells. [3]
        • Ability of the alpha 1b AR subtype tp react faster and to lower levels of norepinephrine may be important in the selective inhibition by stellate cells of specific populations of Purkinje cells. [3]
    Reference