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Details for receptor: alpha-2A adrenoreceptor

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EndoNet ID: ENR00802

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Synonyms

  • alpha2A-AR
  • alpha adrenergic receptor 2A
  • alpha-2A adrenoreceptor

General information

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. [1]
  • The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. [1]
  • For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. [1]
  • The cerebellar cortex expresses mRNA encoding all six alpha adrenergic receptor subtypes (1a, 1b, 1d, 2a, 2b, 2c), whereas dentate nucleus neurons express all subtype mRNAs, except alpha2a adrenergic receptor mRNA. [2]

Links to other resources

UniProt P08913
Ensembl ENST00000449894

Subunit information

Sequence 
MGSLQPDAG NASWNGTEA PGGGARATP 
YSLQVTLTL VCLAGLLML LTVFGNVLV 
IIAVFTSRA LKAPQNLFL VSLASADIL 
VATLVIPFS LANEVMGYW YFGKAWCEI 
YLALDVLFC TSSIVHLCA ISLDRYWSI 
TQAIEYNLK RTPRRIKAI IITVWVISA 
VISFPPLIS IEKKGGGGG PQPAEPRCE 
INDQKWYVI SSCIGSFFA PCLIMILVY 
VRIYQIAKR RTRVPPSRR GPDAVAAPP 
GGTERRPNG LGPERSAGP GGAEAEPLP 
TQLNGAPGE PAPAGPRDT DALDLEESS 
SSDHAERPP GPRRPERGP RGKGKARAS 
QVKPGDSLP RRGPGATGI GTPAAGPGE 
ERVGAAKAS RWRGRQNRE KRFTFVLAV 
VIGVFVVCW FPFFFTYTL TAVGCSVPR 
TLFKFFFWF GYCNSSLNP VIYTIFNHD 
FRRAFKKIL CRGDRKRIV

Binding hormones

  • dopamine
  • serotonin
  • norepinephrine
  • epinephrine

Anatomical structures with this receptor

  • cerebellar_cortex

    Influences

    • negative norepinephrine
      • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [3]
    • negative acetylcholine
      • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [3]

  • Purkinje_cell

    Induced phenotypes

    • regulation of inhibitory postsynaptic membrane potential
      • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [4]

  • granular_layer_of_cerebellar_cortex

    Induced phenotypes

    • regulation of excitatory postsynaptic membrane potential
      • Alpha 2a AR subtype modulates activity of granule cells, the principal excitatory neurons of the cerebellar cortex, accodring to states of vigilance. [2]

  • basket_cell

  • Golgi_cell

    Induced phenotypes

    • regulation of inhibitory postsynaptic membrane potential
      • Alpha 2a subtype modulates activity of golgi cells (inhibitory interneurons) according to states of vigilance. [2]

  • cerebellar_cortex

Reference