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Details for receptor: alpha-2B adrenoreceptor

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EndoNet ID: ENR00803

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Synonyms

  • alpha2B-AR
  • alpha-2B adrenergic receptor
  • alpha-2B adrenoreceptor

General information

  • The cerebellar cortex expresses mRNA encoding all six alpha adrenergic receptor subtypes (1a, 1b, 1d, 2a, 2b, 2c), whereas dentate nucleus neurons express all subtype mRNAs, except alpha2a adrenergic receptor mRNA. [1]
  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. [2]
  • The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. [2]
  • For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. [2]

Links to other resources

UniProt P18089
Ensembl ENST00000409345

Subunit information

Sequence 
MDHQDPYSV QATAAIAAA ITFLILFTI 
FGNALVILA VLTSRSLRA PQNLFLVSL 
AAADILVAT LIIPFSLAN ELLGYWYFR 
RTWCEVYLA LDVLFCTSS IVHLCAISL 
DRYWAVSRA LEYNSKRTP RRIKCIILT 
VWLIAAVIS LPPLIYKGD QGPQPRGRP 
QCKLNQEAW YILASSIGS FFAPCLIMI 
LVYLRIYLI AKRSNRRGP RAKGGPGQG 
ESKQPRPDH GGALASAKL PALASVASA 
REVNGHSKS TGEKEEGET PEDTGTRAL 
PPSWAALPN SGQGQKEGV CGASPEDEA 
EEEEEEEEE EEECEPQAV PVSPASACS 
PPLQQPQGS RVLATLRGQ VLLGRGVGA 
IGGQWWRRR AQLTREKRF TFVLAVVIG 
VFVLCWFPF FFSYSLGAI CPKHCKVPH 
GLFQFFFWI GYCNSSLNP VIYTIFNQD 
FRRAFRRIL CRPWTQTAW

Binding hormones

  • serotonin
  • norepinephrine
  • epinephrine
  • dopamine

Anatomical structures with this receptor

  • cerebellar_cortex

    Influences

    • negative norepinephrine
      • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [3]
    • negative acetylcholine
      • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [3]

  • dentate_nucleus

  • Purkinje_cell

    Induced phenotypes

    • regulation of inhibitory postsynaptic membrane potential
      • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [4]

  • granular_layer_of_cerebellar_cortex

    Induced phenotypes

    • regulation of excitatory postsynaptic membrane potential
      • Alpha 2b AR subtype provides modulation of granule cells appropriate to the strength of glutamatergic input. [1]

  • basket_cell

  • Golgi_cell

    Induced phenotypes

    • regulation of inhibitory postsynaptic membrane potential
      • Alpha 2b AR subtype provides modulation of golgi cells appropriate to the strength of glutamatergic input. [1]

  • cerebellar_cortex

Reference