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Details for receptor: alpha-2C adrenoreceptor

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EndoNet ID: ENR00804

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Synonyms

  • alpha2C-AR
  • alpha-2C adrenergic receptor
  • alpha-2C adrenoreceptor

General information

  • The cerebellar cortex expresses mRNA encoding all six alpha adrenergic receptor subtypes (1a, 1b, 1d, 2a, 2b, 2c), whereas dentate nucleus neurons express all subtype mRNAs, except alpha2a adrenergic receptor mRNA. [1]
  • Transcripts encoding each of the three cloned alpha 2-adrenoceptor subtypes (C2, C4 and C10) were detected in the clonal beta-cell line. [2]

Links to other resources

UniProt P18825
Ensembl ENST00000330055

Subunit information

isoform 1

Sequence 
MASPALAAA LAVAAAAGP NASGAGERG 
SGGVANASG ASWGPPRGQ YSAGAVAGL 
AAVVGFLIV FTVVGNVLV VIAVLTSRA 
LRAPQNLFL VSLASADIL VATLVMPFS 
LANELMAYW YFGQVWCGV YLALDVLFC 
TSSIVHLCA ISLDRYWSV TQAVEYNLK 
RTPRRVKAT IVAVWLISA VISFPPLVS 
LYRQPDGAA YPQCGLNDE TWYILSSCI 
GSFFAPCLI MGLVYARIY RVAKLRTRT 
LSEKRAPVG PDGASPTTE NGLGAAAGA 
GENGHCAPP PADVEPDES SAAAERRRR 
RGALRRGGR RRAGAEGGA GGADGQGAG 
PGAAESGAL TASRSPGPG GRLSRASSR 
SVEFFLSRR RRARSSVCR RKVAQAREK 
RFTFVLAVV MGVFVLCWF PFFFSYSLY 
GICREACQV PGPLFKFFF WIGYCNSSL 
NPVIYTVFN QDFRRSFKH ILFRRRRRG 
FRQ
UniProt P18825-1

Binding hormones

    Anatomical structures with this receptor

    • cerebellar_cortex

      Influences

      • negative norepinephrine
        • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [3]
      • negative acetylcholine
        • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [3]

    • Purkinje_cell

      Induced phenotypes

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [4]

    • beta_cell_of_islet_of_Langerhans

      Influences

      • negative insulin
        • A third mechanism for adrenaline-induced glucose elevation is inhibition of insulin release from the beta-cell mediated by alpha2-adrenoceptors. [5]
    Reference