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Details for receptor: beta-1 adrenoreceptor

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EndoNet ID: ENR00805

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Synonyms

  • beta-1 adrenoreceptor
  • beta1-AR
  • beta-1 adrenoceptor
  • beta1
  • beta 1 adrenergic receptor

General information

  • Beta(1)-adrenergic receptor mRNA expressions in myocardium were significantly lower in patients with heart failure than those in control subjects, and progressively reduced with aggravation of heart function. [1]
  • Flow cytometry showed the presence of beta1 and beta2 adrenoreceptors on resting mast cells. [2]
  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. [3]

Links to other resources

UniProt P08588
Ensembl ENST00000369295

Subunit information

Sequence 
MGAGVLVLG ASEPGNLSS AAPLPDGAA 
TAARLLVPA SPPASLLPP ASESPEPLS 
QQWTAGMGL LMALIVLLI VAGNVLVIV 
AIAKTPRLQ TLTNLFIMS LASADLVMG 
LLVVPFGAT IVVWGRWEY GSFFCELWT 
SVDVLCVTA SIETLCVIA LDRYLAITS 
PFRYQSLLT RARARGLVC TVWAISALV 
SFLPILMHW WRAESDEAR RCYNDPKCC 
DFVTNRAYA IASSVVSFY VPLCIMAFV 
YLRVFREAQ KQVKKIDSC ERRFLGGPA 
RPPSPSPSP VPAPAPPPG PPRPAAAAA 
TAPLANGRA GKRRPSRLV ALREQKALK 
TLGIIMGVF TLCWLPFFL ANVVKAFHR 
ELVPDRLFV FFNWLGYAN SAFNPIIYC 
RSPDFRKAF QRLLCCARR AARRRHATH 
GDRPRASGC LARPGPPPS PGAASDDDD 
DDVVGATPP ARLLEPWAG CNGGAAADS 
DSSLDEPCR PGFASESKV

Binding hormones

  • epinephrine
    (trough: blood
    )
    • This receptor binds epinephrine and norepinephrine with approximatively equal affinity. [3]
  • norepinephrine
    • This receptor binds epinephrine and norepinephrine with approximatively equal affinity. [3]

Anatomical structures with this receptor

  • cardiac_muscle

    Induced phenotypes

    • positive regulation of cardiac muscle contraction
      • Actions of the beta1 receptor include the increase in cardiac output via increasing the heart rate in the sinotrial node,increasing atrial cardiac muscle contractility, increasing contractility and automaticity of the ventricular cardiac muscle and increasing conduction and automaticity of the atrioventricular node. [4]

  • mast_cell

    Induced phenotypes

    • negative regulation of angiogenesis
      • Blockade of β1- and β2-adrenoceptors increases the number of mast cells, promoting proliferation and differentiation of fibroblasts. Additionally, blockade of β1- and β2-adrenoceptors increases the migration of mast cells, resulting in increased angiogenesis. [5]

  • pineal_cell

    Influences

    • positive melatonin

  • fat_cell

    Influences

    • negative leptin
      • Catecholamines suppress leptin release from in vitro differentiated subcutaneous human adipocytes via b1- and b2-adrenergic receptors. [6]

  • kidney

    Influences

    • positive renin
      • renin secretion from juxtaglomerular cells is mediated by the action on β1-adrenoreceptors of norepinephrine released from renal sympathetic nerve terminals as a result of renal nerve activity [7]
Reference