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Details for receptor: beta-2 adrenoreceptor

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EndoNet ID: ENR00806

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Synonyms

  • beta-2 adrenoreceptor
  • ADRB2
  • beta2-AR
  • beta-2 adrenoceptor
  • beta-2 adrenergic receptor
  • ADRB2R
  • BETA2AR
  • adrenergic, beta-2-, receptor, surface
  • catecholamine receptor
  • beta(2)-adrenergic receptor

General information

  • The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. [1]
  • No difference was observed in beta(2)-adrenergic receptor expression between patients with heart failure than those in controls. [2]
  • Studies on patients with early rheumatoid arthritis, untreated with glucocorticoids, indicate that the expression of beta2-adrenoceptors on lymphocytes is reduced. [3]
  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. [4]
  • CGRP-R, NPY-R, VIP-1R and beta2-R, but not SP-R, VIP-2R, PACAP-R, beta1-R and beta3-R, were expressed in osteoblasts as well as osteosarcoma cells. [5]
  • Flow cytometry showed the presence of beta1 and beta2 adrenoreceptors on resting mast cells. [6]
  • Hybridisation of sections of human pancreas with oligodeoxynucleotide probes designed to hybridise with beta 2-adrenoceptor mRNA revealed expression of this species in islet beta-cells but not in the exocrine tissue of the pancreas. [7]
  • The number of beta2-adrenoceptors on peripheral blood mononuclear cells (PBMCs) is increased in healthy subjects, but not in systemic lupus erythematosus (SLE) patients, during periods of stress. [3]

Links to other resources

UniProt P07550
Ensembl ENST00000305988

Subunit information

Sequence 
MGQPGNGSA FLLAPNRSH APDHDVTQQ 
RDEVWVVGM GIVMSLIVL AIVFGNVLV 
ITAIAKFER LQTVTNYFI TSLACADLV 
MGLAVVPFG AAHILMKMW TFGNFWCEF 
WTSIDVLCV TASIETLCV IAVDRYFAI 
TSPFKYQSL LTKNKARVI ILMVWIVSG 
LTSFLPIQM HWYRATHQE AINCYANET 
CCDFFTNQA YAIASSIVS FYVPLVIMV 
FVYSRVFQE AKRQLQKID KSEGRFHVQ 
NLSQVEQDG RTGHGLRRS SKFCLKEHK 
ALKTLGIIM GTFTLCWLP FFIVNIVHV 
IQDNLIRKE VYILLNWIG YVNSGFNPL 
IYCRSPDFR IAFQELLCL RRSSLKAYG 
NGYSSNGNT GEQSGYHVE QEKENKLLC 
EDLPGTEDF VGHQGTVPS DNIDSQGRN 
CSTNDSLL

Binding hormones

  • norepinephrine
  • epinephrine
    • The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. [4]

Anatomical structures with this receptor

  • cardiac_muscle

    Induced phenotypes

    • positive regulation of cardiac muscle contraction
      • Beta2 adrenoreceptors increase the cardiac output to a minor degree compared to beta1 adrenoreceptors. [8]

  • mast_cell

    Influences

    • negative histamine
      • Beta2 adrenoreceptor inhibit the histamine release from mast cells. [9]

    Induced phenotypes

    • negative regulation of angiogenesis
      • Blockade of β1- and β2-adrenoceptors increases the number of mast cells, promoting proliferation and differentiation of fibroblasts. Additionally, blockade of β1- and β2-adrenoceptors increases the migration of mast cells, resulting in increased angiogenesis. [10]

  • osteoblast

    Influences

    • positive interleukin 6
      • The maximum level of IL-6 production was over 40 pg/mL after 6 hr. The maximum level of IL-6 production was obtained at 10–100 μM epinephrine. [11]
    • positive IL-11
      • Interleukin-6 and interleukin-11 synthesis is stimulated by epinephrine in human osteoblasts. [11]

  • beta_cell_of_islet_of_Langerhans

    Influences

    • positive insulin
      • The hypoglycaemia unawareness in patients with insulin dependent diabetes mellitus was associated with dysfunction of the proximal beta2-adrenergic signal pathway. [12]

  • peripheral blood mononuclear cell (PBMC)

  • lymphocyte

  • fat_cell

    Influences

    • negative PAI-1
      • Catecholamines are able to down-regulate PAI-1 expression and secretion in human adipocytes via beta-adrenergic receptors. [13]
    • negative leptin
      • Catecholamines suppress leptin release from in vitro differentiated subcutaneous human adipocytes via b1- and b2-adrenergic receptors. [14]

  • adipose_tissue

    Influences

    • negative leptin
      • Catecholamines (beta 2 adrenoreceptor), cAMP agonists, and peroxisome proliferator-activated receptor gamma (PPAR-gamma) inhibit leptin synthesis and secretion. [15]
Reference