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Details for receptor: beta-3 adrenoreceptor

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EndoNet ID: ENR00807

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Synonyms

  • beta3-AR
  • beta-3 adrenoreceptor
  • beta-3 adrenoceptor
  • beta-3 adrenergic receptor

General information

  • Beta(3)-adrenoceptor mRNA expressions were significantly higher in patients with heart failure than those in controls, and progressively elevated with aggravation of cardiac function. [1]
  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. [2]
  • Adipocytes express beta-1, beta-2 and beta-3 adrenoreceptors. [3]

Links to other resources

UniProt P13945
Ensembl ENST00000345060

Subunit information

Sequence 
MAPWPHENS SLAPWPDLP TLAPNTANT 
SGLPGVPWE AALAGALLA LAVLATVGG 
NLLVIVAIA WTPRLQTMT NVFVTSLAA 
ADLVMGLLV VPPAATLAL TGHWPLGAT 
GCELWTSVD VLCVTASIE TLCALAVDR 
YLAVTNPLR YGALVTKRC ARTAVVLVW 
VVSAAVSFA PIMSQWWRV GADAEAQRC 
HSNPRCCAF ASNMPYVLL SSSVSFYLP 
LLVMLFVYA RVFVVATRQ LRLLRGELG 
RFPPEESPP APSRSLAPA PVGTCAPPE 
GVPACGRRP ARLLPLREH RALCTLGLI 
MGTFTLCWL PFFLANVLR ALGGPSLVP 
GPAFLALNW LGYANSAFN PLIYCRSPD 
FRSAFRRLL CRCGRRLPP EPCAAARPA 
LFPSGVPAA RSSPAQPRL CQRLDGASW 
GVS

Binding hormones

  • epinephrine
  • norepinephrine

Anatomical structures with this receptor

  • cardiac_muscle

  • adipose_tissue

    Induced phenotypes

    • positive regulation of lipid catabolic process
      • Beta-3 adrenoreceptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [4]

  • fat_cell

    Influences

    • positive insulin
      • b3-Adrenergic receptors (b3-ARs) are expressed predominantly on white and brown adipocytes, and acute treatment of mice with CL 316,243, a potent and highly selective b3-AR agonist, produces a 2-fold increase in energy expenditure, a 50–100-fold increase in insulin levels, and a 40–50% reduction in food intake. [5]
      • CL-mediated effects on insulin levels and food intake and only minimally restored effects on oxygen consumption, indicating that any effect on insulin secretion and food intake, and a full stimulation of oxygen consumption required the presence of b3-ARs in white adipocytes. [5]

  • beta_cell_of_islet_of_Langerhans

    Influences

    • positive insulin
      • Human Beta3-AR produced an increased baseline and ligand-dependent insulin secretion. [6]
      • Cells express the Beta3-AR, and its activation contributes to the regulation of insulin secretion. [6]
Reference