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Details for receptor: 5-HT-1A

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EndoNet ID: ENR00822

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Synonyms

  • 5-HT-1A
  • serotonin receptor 1A
  • 5-HT1A
  • 5-hydroxytryptamine 1A receptor

General information

  • 5-HT-1A activates the epileptiform activity of spike-wave discharges. [1]

Links to other resources

UniProt P08908
Ensembl ENST00000323865

Binding hormones

  • serotonin

Anatomical structures with this receptor

  • hippocampus

    Induced phenotypes

    • supression of cAMP production
      • Agonist binding at the receptor leads to G-protein-mediated suppression of cAMP production and enhanced K+-channel conductance. [2]
    • The 5-HT-1A receptors are located on the postsynaptic targets of seretonergic afferents. [3]
    • 5-HT-1A activation results in the opening of the K+ channels, thereby producing membrane hyperpolarization and a decrease in membrane resistance. [4]
    • The activation of the postsynaptic receptor facilitate 5-HT (serotonin) neurotransmission. [5]

  • amygdaloid_body

    Influences

    • negative GABA
      • Activated 5-HT-1A receptors inhibite GABA release in the basolateral amygdala. [6]
    • Activated 5-HT-1A receptors inhibite GABA release in the basolateral amygdala. [6]

  • posterior_raphe_nucleus_of_midbrain

    Influences

    • negative serotonin
      • The activation of somatodendritic autoreceptors inhibit the electric activity of serotoninergic neurons, thereby reducing serotonin release and neurotransmission. [5]
    • Somatodendritic 5-HT-1A autoreceptors located on the 5-hydroxytryptaminergic neurones in the dorsal raphe nucleus. [7]
    • 5-HT-1A activation results in the opening of the K+ channels, thereby producing membrane hyperpolarization and a decrease in membrane resistance. [4]
    • The activation of somatodendritic autoreceptors inhibit the electric activity of serotoninergic neurons, thereby reducing serotonin release and neurotransmission. [5]

  • pyramidal_layer_of_hippocampus

    Induced phenotypes

    • anxiety behavior
      • Knock-out of 5-HT-1A leads to anxiety-like behavior (avoidance of novel environments and escape from stressful situations). [8]
    • Serotonin activation of the 5-HT-1A recpetors mediate hyperpolarization of pyramidal cells of layer V. [9]
Reference