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Details for receptor: NPY2-R

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EndoNet ID: ENR00824

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Synonyms

  • NPY2-R
  • neuropeptide Y receptor type 2
  • NPY-Y2 receptor
  • NPY2R

General information

  • Rank order of affinity of this receptor is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. [1]
  • The NPY Y2 receptor, a putative inhibitory presynaptic receptor, is highly expressed on NPY neurons in the arcuate nucleus. [2]
  • High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus, detectable in caudate nucleus, hypothalamus and substantia nigra. [1]

Links to other resources

UniProt P49146
Ensembl ENST00000393843

Subunit information

Sequence 
MGPIGAEAD ENQTVEEMK VEQYGPQTT 
PRGELVPDP EPELIDSTK LIEVQVVLI 
LAYCSIILL GVIGNSLVI HVVIKFKSM 
RTVTNFFIA NLAVADLLV NTLCLPFTL 
TYTLMGEWK MGPVLCHLV PYAQGLAVQ 
VSTITLTVI ALDRHRCIV YHLESKISK 
RISFLIIGL AWGISALLA SPLAIFREY 
SLIEIIPDF EIVACTEKW PGEEKSIYG 
TVYSLSSLL ILYVLPLGI ISFSYTRIW 
SKLKNHVSP GAANDHYHQ RRQKTTKML 
VCVVVVFAV SWLPLHAFQ LAVDIDSQV 
LDLKEYKLI FTVFHIIAM CSTFANPLL 
YGWMNSNYR KAFLSAFRC EQRLDAIHS 
EVSVTFKAK KNLEVRKNS GPNDSFTEA 
TNV

Binding hormones

  • PYY (1-36)
  • NPY
  • PYY(3-36)

Anatomical structures with this receptor

  • amygdaloid_body

  • corpus_callosum

  • hippocampus

  • caudate_nucleus

  • substantia_nigra

  • subthalamic_nucleus

  • hypothalamus

    Influences

    • negative NPY
      • PYY(3-36) binding to NPY2-R inhibits orexigenic NPY in hypothalamus causing short-term inhibition of food intake [3]

  • arcuate_nucleus_of_hypothalamus

    Influences

    • negative NPY
    • negative AGRP

    Induced phenotypes

    • negative regulation of appetite
      • The short form of peptide YY (PYY3-36) is cleaved from the long form (PYY1-36) by the enzyme dipeptidyl peptidase IV, and decreases food intake when administered peripherally. [4]
      • The anorectic effect of PYY3-36 requires Y2 receptors because it fails to inhibit food intake in Y2 receptor-knockout mice. PYY3-36 decreased NPY mRNA in the ARC and its direct delivery into the ARC was sufficient to decrease food intake, highlighting the probable importance of NPY cells in the anorectic effect of PYY3-36. [5]
      • The effects of PYY3-36 in decreasing food intake are are due to a combination of various mechanisms involving different brain areas (independent of the melanocortin system. [5]
    • positive regulation of appetite
      • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [5]
Reference