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Details for receptor: CB2

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EndoNet ID: ENR00826

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • cannabinoid receptor 2
  • CB-2
  • CX5
  • CNR2
  • CB2

General information

  • Potential therapeutic uses of cannabinoid receptoragonistsinclude themanagement of multiple sclerosis/spinal cord injury, pain, inflammatory disorders, glaucoma, bronchial asthma, vasodilation that accompanies advanced cirrhosis, and cancer. [1]
  • Seem to include the modulation of cytokine release [1]

Links to other resources

UniProt P34972
Ensembl ENST00000374472

Subunit information

Sequence 
MEECWVTEI ANGSKDGLD SNPMKDYMI 
LSGPQKTAV AVLCTLLGL LSALENVAV 
LYLILSSHQ LRRKPSYLF IGSLAGADF 
LASVVFACS FVNFHVFHG VDSKAVFLL 
KIGSVTMTF TASVGSLLL TAIDRYLCL 
RYPPSYKAL LTRGRALVT LGIMWVLSA 
LVSYLPLMG WTCCPRPCS ELFPLIPND 
YLLSWLLFI AFLFSGIIY TYGHVLWKA 
HQHVASLSG HQDRQVPGM ARMRLDVRL 
AKTLGLVLA VLLICWFPV LALMAHSLA 
TTLSDQVKK AFAFCSMLC LINSMVNPV 
IYALRSGEI RSSAHHCLA HWKKCVRGL 
GSEAKEEAP RSSVTETEA DGKITPWPD 
SRDLDLSDC

Binding hormones

  • Virodhamine
    • Virodhamine was less potent than anandamide and 2-AG at both CB1 and CB2. [2]
  • anandamide (20:4, n-6)
    • anandamide behaves as a partial cannabinoid receptor agonist with marginally greater CB1 than CB2 affinity but much less CB2 than CB1 efficacy. [1]
  • 2-Arachidonyl glycerol ether
  • 2-Arachidonoylglycerol

Anatomical structures with this receptor

  • leukocyte

Reference