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Details for receptor: mGluR1

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  • General information
  • Subunits
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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00827

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Synonyms

  • mGluR1
  • metabotropic glutamate receptor 1

General information

  • mGluR1 and mGluR5 participate in regulating synaptic transmission and pyramidal cell excitability in hippocampal area CA1. [1]

Links to other resources

UniProt Q13255
Ensembl ENST00000392299

Subunit information

isoform alpha (1 times)

Sequence 
LPRSPGRKV LLAGASSQR SVARMDGDV 
IIGALFSVH HQPPAEKVP ERKCGEIRE 
QYGIQRVEA MFHTLDKIN ADPVLLPNI 
TLGSEIRDS CWHSSVALE QSIEFIRDS 
LISIRDEKD GINRCLPDG QSLPPGRTK 
KPIAGVIGP GSSSVAIQV QNLLQLFDI 
PQIAYSATS IDLSDKTLY KYFLRVVPS 
DTLQARAML DIVKRYNWT YVSAVHTEG 
NYGESGMDA FKELAAQEG LCIAHSDKI 
YSNAGEKSF DRLLRKLRE RLPKARVVV 
CFCEGMTVR GLLSAMRRL GVVGEFSLI 
GSDGWADRD EVIEGYEVE ANGGITIKL 
QSPEVRSFD DYFLKLRLD TNTRNPWFP 
EFWQHRFQC RLPGHLLEN PNFKRICTG 
NESLEENYV QDSKMGFVI NAIYAMAHG 
LQNMHHALC PGHVGLCDA MKPIDGSKL 
LDFLIKSSF IGVSGEEVW FDEKGDAPG 
RYDIMNLQY TEANRYDYV HVGTWHEGV 
LNIDDYKIQ MNKSGVVRS VCSEPCLKG 
QIKVIRKGE VSCCWICTA CKENEYVQD 
EFTCKACDL GWWPNADLT GCEPIPVRY 
LEWSNIESI IAIAFSCLG ILVTLFVTL 
IFVLYRDTP VVKSSSREL CYIILAGIF 
LGYVCPFTL IAKPTTTSC YLQRLLVGL 
SSAMCYSAL VTKTNRIAR ILAGSKKKI 
CTRKPRFMS AWAQVIIAS ILISVQLTL 
VVTLIIMEP PMPILSYPS IKEVYLICN 
TSNLGVVAP LGYNGLLIM SCTYYAFKT 
RNVPANFNE AKYIAFTMY TTCIIWLAF 
VPIYFGSNY KIITTCFAV SLSVTVALG 
CMFTPKMYI IIAKPERNV RSAFTTSDV 
VRMHVGDGK LPCRSNTFL NIFRRKKAG 
AGNANSNGK SVSWSEPGG GQVPKGQHM 
WHRLSVHVK TNETACNQT AVIKPLTKS 
YQGSGKSLT FSDTSTKTL YNVEEEEDA 
QPIRFSPPG SPSMVVHRR VPSAATTPP 
LPPHLTAEE TPLFLAEPA LPKGLPPPL 
QQQQQPPPQ QKSLMDQLQ GVVSNFSTA 
IPDFHAVLA GPGGPGNGL RSLYPPPPP 
PQHLQMLPL QLSTFGEEL VSPPADDDD 
DSERFKLLQ EYVYEHERE GNTEEDELE 
EEEEDLQAA SKLTPDDSP ALTPPSPFR 
DSVASGSSV PSSPVSESV LCTPPNVSY 
ASVILRDYK QSSSTL
UniProt Q13255-1

Binding hormones

  • glutamate

Anatomical structures with this receptor

  • pyramidal_layer_of_hippocampus

  • hippocampus

    Influences

    • positive sAPP
      • Glutamate-induced APP-S secretion required activation of phospholipase C, which resulted in inositol 1, 4,5-trisphosphate production, as shown by the rapid glutamate-induced accumulation of inositol 1,4,5-trisphosphate. [2]

  • cerebral_cortex

    Influences

    • positive sAPP
      • Glutamate-induced APP-S secretion required activation of phospholipase C, which resulted in inositol 1, 4,5-trisphosphate production, as shown by the rapid glutamate-induced accumulation of inositol 1,4,5-trisphosphate. [2]
Reference