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Details for receptor: CXCR4

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EndoNet ID: ENR00836

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Synonyms

  • CXCR4
  • stromal cell-derived factor 1 receptor
  • SDF-1 receptor
  • fusin
  • LESTR
  • C-X-C chemokine receptor type 4
  • CD184 antigen

General information

  • SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. [1]
  • The chemokine stromal cell-derived factor-1 and its receptor, CXCR4, play a major role in migration, retention, and development of hematopoietic progenitors in the bone marrow. [2]
  • CXCR4 serves as a fusion cofactor for lymphotropic strains of human immunodeficiency virus type 1 and SDF1 inhibits viral entry. [3]

Links to other resources

UniProt P30991

Subunit information

isoform 1

Sequence 
MEGISIYTS DNYTEEMGS GDYDSMKEP 
CFREENANF NKIFLPTIY SIIFLTGIV 
GNGLVILVM GYQKKLRSM TDKYRLHLS 
VADLLFVIT LPFWAVDAV ANWYFGNFL 
CKAVHVIYT VNLYSSVLI LAFISLDRY 
LAIVHATNS QRPRKLLAE KVVYVGVWI 
PALLLTIPD FIFANVSEA DDRYICDRF 
YPNDLWVVV FQFQHIMVG LILPGIVIL 
SCYCIIISK LSHSKGHQK RKALKTTVI 
LILAFFACW LPYYIGISI DSFILLEII 
KQGCEFENT VHKWISITE ALAFFHCCL 
NPILYAFLG AKFKTSAQH ALTSVSRGS 
SLKILSKGK RGGHSSVST ESESSSFHS 
S

Binding hormones

  • SDF-1alpha
  • SDF-1beta

Anatomical structures with this receptor

  • monocyte

  • killer_cell

  • hypothalamus

    Influences

    • negative antidiuretic hormone
      • In acute stimulation conditions, such as an increase in osmolarity or Angiotensin II, SDF-1/CXCL12 co-localized with AVP can be somatodendritically released and inhibit AVP release by an autoregulatory mechanism involving its receptor CXCR4. In conditions in which AVP is chronically stimulated, such as dehydration, SDF-1/CXCL12 is strongly released, resulting in a down-regulation of CXCR4. Such down-regulation of the receptor blocks the inhibitory effect of SDF-1/CXCL12 on AVP release, allowing a sustained increase in AVP secretion. [4]

  • pituitary_gland_of_diencephalon

    Influences

    • positive GH
      • SDF-1-alpha /CXCL12 causes both proliferation and growth hormone release, suggesting that the activation of CXCR4 may represent a novel regulatory mechanism for growth hormone secretion and pituitary cell proliferation, which may contribute to pituitary adenoma development. [5]
Reference