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Details for receptor: CCR5

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EndoNet ID: ENR00837

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Synonyms

  • CCR5
  • C-C chemokine receptor type 5
  • HIV-1 fusion coreceptor

General information

  • Binds to MIP-1-alpha, MIP-1-beta and RANTES. [1]

Links to other resources

UniProt P51681
Ensembl ENST00000445772

Subunit information

Sequence 
MDYQVSSPI YDINYYTSE PCQKINVKQ 
IAARLLPPL YSLVFIFGF VGNMLVILI 
LINCKRLKS MTDIYLLNL AISDLFFLL 
TVPFWAHYA AAQWDFGNT MCQLLTGLY 
FIGFFSGIF FIILLTIDR YLAVVHAVF 
ALKARTVTF GVVTSVITW VVAVFASLP 
GIIFTRSQK EGLHYTCSS HFPYSQYQF 
WKNFQTLKI VILGLVLPL LVMVICYSG 
ILKTLLRCR NEKKRHRAV RLIFTIMIV 
YFLFWAPYN IVLLLNTFQ EFFGLNNCS 
SSNRLDQAM QVTETLGMT HCCINPIIY 
AFVGEKFRN YLLVFFQKH IAKRFCKCC 
SIFQQEAPE RASSVYTRS TGEQEISVG 
L

Binding hormones

  • MIP-1 alpha
  • MIP-1 beta
  • RANTES
  • HCC-1
    • Is a ligand for CCR1, CCR3 and CCR5
  • alpha-AGP
    • Taken together, these data indicate that AGP binds to CCR5 on monocyte-derived macrophages. [2]

Anatomical structures with this receptor

  • lipocyte_of_liver

    Influences

    • positive RANTES
      • Hepatic stellate cell derived RANTES acts on hepatic stellate cells in an autocrine fashion. [3]
      • Activated hepatic stellate cells express CCR5 and respond to recombinant human (rh)RANTES stimulation with an increase in proliferation and migration in a CCR5-dependent manner. [3]
      • Even under inflammatory conditions, RANTES would exert biological effects in a paracrine rather than an autocrine fashion. [3]

    Induced phenotypes

    • hepatic stellate cell migration
      • RANTES potently stimulates the migration of hepatic stellate cells due to binding to CCR5, and induces FAK phosphorylation. [3]
    • ERK activation
      • RANTES induces the activation of ERK this biological effect is mediated by CCR5. [3]
    • positive regulation of cell proliferation
      • RANTES stimulates [3H]thymidine incorporation and hepatic stellate cell proliferation in a redox- and intracellular calium-dependent manner, this biological effect is mediated by CCR5. [3]

  • monocyte

Reference