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Details for receptor: TLR3

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EndoNet ID: ENR00842

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Synonyms

  • toll-like receptor 3
  • TLR3
  • CD283 antigen

General information

  • TLR3 was only expressed in human dendritic cells (DC) wherein maturation induced by bacterial products or cytokines was associated with reduced expression. [1]
  • Participates in the innate immune response to microbial agents. May be involved in the recognition of ds-RNA. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [2]
  • Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. [2]

Links to other resources

UniProt O15455
Ensembl ENST00000296795

Subunit information

Sequence 
STTKCTVSH EVADCSHLK LTQVPDDLP 
TNITVLNLT HNQLRRLPA ANFTRYSQL 
TSLDVGFNT ISKLEPELC QKLPMLKVL 
NLQHNELSQ LSDKTFAFC TNLTELHLM 
SNSIQKIKN NPFVKQKNL ITLDLSHNG 
LSSTKLGTQ VQLENLQEL LLSNNKIQA 
LKSEELDIF ANSSLKKLE LSSNQIKEF 
SPGCFHAIG RLFGLFLNN VQLGPSLTE 
KLCLELANT SIRNLSLSN SQLSTTSNT 
TFLGLKWTN LTMLDLSYN NLNVVGNDS 
FAWLPQLEY FFLEYNNIQ HLFSHSLHG 
LFNVRYLNL KRSFTKQSI SLASLPKID 
DFSFQWLKC LEHLNMEDN DIPGIKSNM 
FTGLINLKY LSLSNSFTS LRTLTNETF 
VSLAHSPLH ILNLTKNKI SKIESDAFS 
WLGHLEVLD LGLNEIGQE LTGQEWRGL 
ENIFEIYLS YNKYLQLTR NSFALVPSL 
QRLMLRRVA LKNVDSSPS PFQPLRNLT 
ILDLSNNNI ANINDDMLE GLEKLEILD 
LQHNNLARL WKHANPGGP IYFLKGLSH 
LHILNLESN GFDEIPVEV FKDLFELKI 
IDLGLNNLN TLPASVFNN QVSLKSLNL 
QKNLITSVE KKVFGPAFR NLTELDMRF 
NPFDCTCES IAWFVNWIN ETHTNIPEL 
SSHYLCNTP PHYHGFPVR LFDTSSCKD 
SAPFELFFM INTSILLIF IFIVLLIHF 
EGWRISFYW NVSVHRVLG FKEIDRQTE 
QFEYAAYII HAYKDKDWV WEHFSSMEK 
EDQSLKFCL EERDFEAGV FELEAIVNS 
IKRSRKIIF VITHHLLKD PLCKRFKVH 
HAVQQAIEQ NLDSIILVF LEEIPDYKL 
NHALCLRRG MFKSHCILN WPVQKERIG 
AFRHKLQVA LGSKNSVH

Binding hormones

    Anatomical structures with this receptor

    • dendritic_cell_in_lymphoid_tissues

      Influences

      • positive IFN-alpha
        • TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. [3]
      • positive IFN-beta
        • TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. [3]
      • positive IL-8
        • RNA, likely through secondary structure, is a potent host-derived activator of TLR3. Exposing cells human embryonic kidney 293 cells stably expressing TLR3 and containing a nuclear factor-kB-dependent luciferase reporter) to in vitro transcribed RNA resulted in a TLR3-dependent induction of luciferase activity and interleukin-8 secretion. [4]

    • placenta

    • pancreas

    • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • epithelial_cell_with_microvilli

    • vaginal_mucosa

    • cervical_canal_of_uterus

    • cholangiocyte

    • bronchial_epithelial_cell

    • macrophage

      Influences

      • positive IL-1 beta
        • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [5]
    Reference