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Details for receptor: TLR5

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EndoNet ID: ENR00844

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Synonyms

  • toll-like receptor 5
  • TLR5
  • TIL3
  • toll/interleukin-1 receptor- like protein 3

General information

  • Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [1]
  • TLR5 has been associated with responses to bacterial flagellin. [2]
  • TLR5 was increased in monocytes of HCV-infected patients. [3]

Links to other resources

UniProt O60602
Ensembl ENST00000407096

Subunit information

Sequence 
IPSCSFDGR IAFYRFCNL TQVPQVLNT 
TERLLLSFN YIRTVTASS FPFLEQLQL 
LELGSQYTP LTIDKEAFR NLPNLRILD 
LGSSKIYFL HPDAFQGLF HLFELRLYF 
CGLSDAVLK DGYFRNLKA LTRLDLSKN 
QIRSLYLHP SFGKLNSLK SIDFSSNQI 
FLVCEHELE PLQGKTLSF FSLAANSLY 
SRVSVDWGK CMNPFRNMV LEIVDVSGN 
GWTVDITGN FSNAISKSQ AFSLILAHH 
IMGAGFGFH NIKDPDQNT FAGLARSSV 
RHLDLSHGF VFSLNSRVF ETLKDLKVL 
NLAYNKINK IADEAFYGL DNLQVLNLS 
YNLLGELCS SNFYGLPKV AYIDLQKNH 
IAIIQDQTF KFLEKLQTL DLRDNALTT 
IHFIPSIPD IFLSGNKLV TLPKINLTA 
NLIHLSENR LENLDILYF LLRVPHLQI 
LILNQNRFS SCSGDQTPS ENPSLEQLF 
LGENMLQLA WETELCWDV FEGLSHLQV 
LYLNHNYLN SLPPGVFSH LTALRGLSL 
NSNRLTVLS HNDLPANLE ILDISRNQL 
LAPNPDVFV SLSVLDITH NKFICECEL 
STFINWLNH TNVTIAGPP ADIYCVYPD 
SFSGVSLFS LSTEGCDEE EVLKSLKFS 
LFIVCTVTL TLFLMTILT VTKFRGFCF 
ICYKTAQRL VFKDHPQGT EPDMYKYDA 
YLCFSSKDF TWVQNALLK HLDTQYSDQ 
NRFNLCFEE RDFVPGENR IANIQDAIW 
NSRKIVCLV SRHFLRDGW CLEAFSYAQ 
GRCLSDLNS ALIMVVVGS LSQYQLMKH 
QSIRGFVQK QQYLRWPED LQDVGWFLH 
KLSQQILKK EKEKKKDNN IPLQTVATI 
S

Binding hormones

    Anatomical structures with this receptor

    • ovary

    • monocyte

    • prostate

    • testis

    • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • epithelial_cell_with_microvilli

    • vaginal_mucosa

    • cervical_canal_of_uterus

    • cholangiocyte

    • bronchial_epithelial_cell

    • macrophage

      Influences

      • positive IL-1 beta
        • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [4]
    Reference