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Details for receptor: TGFR-3

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  • General information
  • Subunits
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  • General information
  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00848

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http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • TGFbetaR-III
  • transforming growth factor beta receptor III
  • TGFR-3
  • betaglycan

General information

  • Betaglycan is a co-receptor for TGF-beta. [1]
  • Betaglycan also binds inhibin A and participates in a ternary complex composed of the activin type II receptor and inhibin. [1]
  • In placenta, strong immunostaining was identified on the apical surface of the syncytiotrophoblast layer. [2]

Links to other resources

UniProt Q03167
Ensembl ENST00000417833

Subunit information

Sequence 
GPEPGALCE LSPVSASHP VQALMESFT 
VLSGCASRG TTGLPQEVH VLNLRTAGQ 
GPGQLQREV TLHLNPISS VHIHHKSVV 
FLLNSPHPL VWHLKTERL ATGVSRLFL 
VSEGSVVQF SSANFSLTA ETEERNFPH 
GNEHLLNWA RKEYGAVTS FTELKIARN 
IYIKVGEDQ VFPPKCNIG KNFLSLNYL 
AEYLQPKAA EGCVMSSQP QNEEVHIIE 
LITPNSNPY SAFQVDITI DIRPSQEDL 
EVVKNLILI LKCKKSVNW VIKSFDVKG 
SLKIIAPNS IGFGKESER SMTMTKSIR 
DDIPSTQGN LVKWALDNG YSPITSYTM 
APVANRFHL RLENNEEMG DEEVHTIPP 
ELRILLDPG ALPALQNPP IRGGEGQNG 
GLPFPFPDI SRRVWNEEG EDGLPRPKD 
PVIPSIQLF PGLREPEEV QGSVDIALS 
VKCDNEKMI VAVEKDSFQ ASGYSGMDV 
TLLDPTCKA KMNGTHFVL ESPLNGCGT 
RPRWSALDG VVYYNSIVI QVPALGDSS 
GWPDGYEDL ESGDNGFPG DMDEGDASL 
FTRPEIVVF NCSLQQVRN PSSFQEQPH 
GNITFNMEL YNTDLFLVP SQGVFSVPE 
NGHVYVEVS VTKAEQELG FAIQTCFIS 
PYSNPDRMS HYTIIENIC PKDESVKFY 
SPKRVHFPI PQADMDKKR FSFVFKPVF 
NTSLLFLQC ELTLCTKME KHPQKLPKC 
VPPDEACTS LDASIIWAM MQNKKTFTK 
PLAVIHHEA ESKEKGPSM KEPNPISPP 
IFHGLDTLT VMGIAFAAF VIGALLTGA 
LWYIYSHTG ETAGRQQVP TSPPASENS 
SAAHSIGST QSTPCSSSS TA

Binding hormones

  • TGF-beta 2
    • Unlike TGF-beta1 and -beta3, TGF-beta2 appears to require the co-receptor betaglycan (TbetaRIII) for high affinity binding and signaling. [3]
  • inhibin A

Anatomical structures with this receptor

  • cell_of_endometrium_of_uterus

  • placenta

Reference