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Details for receptor: parathyroid hormone 2 receptor

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EndoNet ID: ENR00851

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Synonyms

  • parathyroid hormone 2 receptor
  • PTH2 receptor
  • PTHR2

General information

  • Belongs to the G-protein coupled receptor 2 family. The transmembrane receptors activity is mediated by G proteins which then activates adenylyl cyclase.
  • The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception. [1]

Links to other resources

UniProt P49190
Ensembl ENST00000419079

Subunit information

Parathyroid hormone 2 receptor (1 times)

  • The displayed sequence is further processed into a mature form.
Sequence 
MAGLGASLH VWGWLMLGS CLLARAQLD 
SDGTITIEE QIVLVLKAK VQCELNITA 
QLQEGEGNC FPEWDGLIC WPRGTVGKI 
SAVPCPPYI YDFNHKGVA FRHCNPNGT 
WDFMHSLNK TWANYSDCL RFLQPDISI 
GKQEFFERL YVMYTVGYS ISFGSLAVA 
ILIIGYFRR LHCTRNYIH MHLFVSFML 
RATSIFVKD RVVHAHIGV KELESLIMQ 
DDPQNSIEA TSVDKSQYI GCKIAVVMF 
IYFLATNYY WILVEGLYL HNLIFVAFF 
SDTKYLWGF ILIGWGFPA AFVAAWAVA 
RATLADARC WELSAGDIK WIYQAPILA 
AIGLNFILF LNTVRVLAT KIWETNAVG 
HDTRKQYRK LAKSTLVLV LVFGVHYIV 
FVCLPHSFT GLGWEIRMH CELFFNSFQ 
GFFVSIIYC YCNGEVQAE VKKMWSRWN 
LSVDWKRTP PCGSRRCGS VLTTVTHST 
SSQSQVAAS TRMVLISGK AAKIASRQP 
DSHITLPGY VWSNSEQDC LPHSFHEET 
KEDSGRQGD DILMEKPSR PMESNPDTE 
GCQGETEDV L
UniProt P49190-1

Binding hormones

  • PTH
    • PTH activates PTHR by interacting with a ligand-binding site localized within the N-terminal extracellular domain (the Ndomain) and the domain comprising the seven transmembrane helices and the connecting extracellular loops (the J-domain). [2]
    • The human PTH2 receptor is potently bound and strongly activated by both TIP39 and PTH. [3]
  • TIP39
    • pronociceptive effects of TIP39 were antagonized with intrathecal administration of a TIP39 antibody suggesting that some aspects of nociception are potentiated via the PTH2R [4]
    • The human PTH2 receptor is potently bound and strongly activated by both TIP39 and PTH. [3]

Anatomical structures with this receptor

  • brain

    • The PTH2 receptor is most likely to function in the brain and the pancreas. [5]
    • Independent demonstration of the presence of PTH2R mRNA and immunoreactivity supports the specific expression of the PTH2R in the human brainstem [4]
    • Northern blots show that PTH2R mRNA is most abundant in the brain. [3]

  • pancreas

    • The PTH2 receptor is most likely to function in the brain and pancreas. [5]
    • (PTH2 receptor mRNA) ... is also detected in pancreas, placenta and lung on northern blots [3]

  • testis

    • The PTH2 receptor is most likely to function in the brain and pancreas where its mRNA is particularly abundant, and possibly in the testis and placenta. [5]
    • (PTH2 receptor mRNA) ... is also detected in pancreas, placenta and lung on northern blots [3]

  • placenta

    • The PTH2 receptor is most likely to function in the brain and pancreas where its mRNA is particularly abundant, and possibly in the testis and placenta. [5]
    • (PTH2 receptor mRNA) ... is also detected in pancreas, placenta and lung on northern blots [3]

  • monocyte

    • PTH2 receptor is expressed on human granulocytes and--to a lesser degree--on monocytes and lymphocytes [6]

  • lymphocyte

    • PTH2 receptor is expressed on human granulocytes and--to a lesser degree--on monocytes and lymphocytes [6]

  • neutrophil_granulocyte

    • PTH2 receptor is expressed on human granulocytes and--to a lesser degree--on monocytes and lymphocytes [6]

  • lung

    • (PTH2 receptor mRNA) ... is also detected in pancreas, placenta and lung on northern blots [3]
Reference