Status
Please wait ...

Details for receptor: PDGFRbeta

EndoNet ID: ENR00852

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • PDGFR beta
  • PDGFR-beta
  • PDGFRbeta

General information

  • The PDGF-beta receptor is highly upregulated on activated HSCs. [1]
  • Receptor that binds specifically to PDGFB and PDGFD. [2]

Links to other resources

UniProt P09619
Ensembl ENST00000261799

Subunit information

Subunit (2 times)

Sequence
LVVTPPGPE LVLNVSSTF VLTCSGSAP 
VVWERMSQE PPQEMAKAQ DGTFSSVLT 
LTNLTGLDT GEYFCTHND SRGLETDER 
KRLYIFVPD PTVGFLPND AEELFIFLT 
EITEITIPC RVTDPQLVV TLHEKKGDV 
ALPVPYDHQ RGFSGIFED RSYICKTTI 
GDREVDSDA YYVYRLQVS SINVSVNAV 
QTVVRQGEN ITLMCIVIG NEVVNFEWT 
YPRKESGRL VEPVTDFLL DMPYHIRSI 
LHIPSAELE DSGTYTCNV TESVNDHQD 
EKAINITVV ESGYVRLLG EVGTLQFAE 
LHRSRTLQV VFEAYPPPT VLWFKDNRT 
LGDSSAGEI ALSTRNVSE TRYVSELTL 
VRVKVAEAG HYTMRAFHE DAEVQLSFQ 
LQINVPVRV LELSESHPD SGEQTVRCR 
GRGMPQPNI IWSACRDLK RCPRELPPT 
LLGNSSEEE SQLETNVTY WEEEQEFEV 
VSTLRLQHV DRPLSVRCT LRNAVGQDT 
QEVIVVPHS LPFKVVVIS AILALVVLT 
IISLIILIM LWQKKPRYE IRWKVIESV 
SSDGHEYIY VDPMQLPYD STWELPRDQ 
LVLGRTLGS GAFGQVVEA TAHGLSHSQ 
ATMKVAVKM LKSTARSSE KQALMSELK 
IMSHLGPHL NVVNLLGAC TKGGPIYII 
TEYCRYGDL VDYLHRNKH TFLQHHSDK 
RRPPSAELY SNALPVGLP LPSHVSLTG 
ESDGGYMDM SKDESVDYV PMLDMKGDV 
KYADIESSN YMAPYDNYV PSAPERTCR 
ATLINESPV LSYMDLVGF SYQVANGME 
FLASKNCVH RDLAARNVL ICEGKLVKI 
CDFGLARDI MRDSNYISK GSTFLPLKW 
MAPESIFNS LYTTLSDVW SFGILLWEI 
FTLGGTPYP ELPMNEQFY NAIKRGYRM 
AQPAHASDE IYEIMQKCW EEKFEIRPP 
FSQLVLLLE RLLGEGYKK KYQQVDEEF 
LRSDHPAIL RSQARLPGF HGLRSPLDT 
SSVLYTAVQ PNEGDNDYI IPLPDPKPE 
VADEGPLEG SPSLASSTL NEVNTSSTI 
SCDSPLEPQ DEPEPEPQL ELQVEPEPE 
LEQLPDSGC PAPRAEAED SFL

Binding hormones

  • PDGFD
  • PDGFB
    • A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. [2]

Anatomical structures with this receptor

  • lipocyte_of_liver

    Induced phenotypes

    • regulation of tissue remodeling
      • Dominant-negative soluble PDGF-beta receptor is active as an antifibrogenic protein drug able to reduce the biological effects of PDGF in ongoing fibrogenesis. Therefore, it could be an attractive therapeutic agent for the treatment of fibrotic liver diseases and possibly other fibrotic organ lesions. [3]
      • PDGF plays a critical role in the progression and initiation of experimental liver fibrogenesis, it is important for the activation into a myofibroblastic phenotype. [4]
    • PDGF receptor type b (PDGFRb) is acquired as the cells undergo myofibroblastic phenotypic changes. [5]
Reference