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Details for receptor: PDGFRalpha

EndoNet ID: ENR00853

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Synonyms

  • PDGFR alpha
  • PDGFR-alpha
  • PDGFRalpha

General information

Links to other resources

UniProt P16234
Ensembl ENST00000257290

Subunit information

isoform 1 (2 times)

Sequence
QLSLPSILP NENEKVVQL NSSFSLRCF 
GESEVSWQY PMSEEESSD VEIRNEENN 
SGLFVTVLE VSSASAAHT GLYTCYYNH 
TQTEENELE GRHIYIYVP DPDVAFVPL 
GMTDYLVIV EDDDSAIIP CRTTDPETP 
VTLHNSEGV VPASYDSRQ GFNGTFTVG 
PYICEATVK GKKFQTIPF NVYALKATS 
ELDLEMEAL KTVYKSGET IVVTCAVFN 
NEVVDLQWT YPGEVKGKG ITMLEEIKV 
PSIKLVYTL TVPEATVKD SGDYECAAR 
QATREVKEM KKVTISVHE KGFIEIKPT 
FSQLEAVNL HEVKHFVVE VRAYPPPRI 
SWLKNNLTL IENLTEITT DVEKIQEIR 
YRSKLKLIR AKEEDSGHY TIVAQNEDA 
VKSYTFELL TQVPSSILD LVDDHHGST 
GGQTVRCTA EGTPLPDIE WMICKDIKK 
CNNETSWTI LANNVSNII TEIHSRDRS 
TVEGRVTFA KVEETIAVR CLAKNLLGA 
ENRELKLVA PTLRSELTV AAAVLVLLV 
IVIISLIVL VVIWKQKPR YEIRWRVIE 
SISPDGHEY IYVDPMQLP YDSRWEFPR 
DGLVLGRVL GSGAFGKVV EGTAYGLSR 
SQPVMKVAV KMLKPTARS SEKQALMSE 
LKIMTHLGP HLNIVNLLG ACTKSGPIY 
IITEYCFYG DLVNYLHKN RDSFLSHHP 
EKPKKELDI FGLNPADES TRSYVILSF 
ENNGDYMDM KQADTTQYV PMLERKEVS 
KYSDIQRSL YDRPASYKK KSMLDSEVK 
NLLSDDNSE GLTLLDLLS FTYQVARGM 
EFLASKNCV HRDLAARNV LLAQGKIVK 
ICDFGLARD IMHDSNYVS KGSTFLPVK 
WMAPESIFD NLYTTLSDV WSYGILLWE 
IFSLGGTPY PGMMVDSTF YNKIKSGYR 
MAKPDHATS EVYEIMVKC WNSEPEKRP 
SFYHLSEIV ENLLPGQYK KSYEKIHLD 
FLKSDHPAV ARMRVDSDN AYIGVTYKN 
EEDKLKDWE GGLDEQRLS ADSGYIIPL 
PDIDPVPEE EDLGKRNRH SSQTSEESA 
IETGSSSST FIKREDETI EDIDMMDDI 
GIDSSDLVE DSFL
UniProt P16234-1

Binding hormones

  • PDGFA
    • A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. [1]
  • PDGFB
    • A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. [1]
  • PDGFC

Anatomical structures with this receptor

  • fibroblast

    Induced phenotypes

    • proliferation of fibroblasts
      • PDGF-C, which binds to and activates the PDGF alpha-receptor, is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. [2]
    • Cardiac fibroblasts express PDGFR-alpha. [2]
Reference