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Details for receptor: IL-6R

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EndoNet ID: ENR00864

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Synonyms

  • interleukin 6 receptor
  • IL-6R-alpha
  • interleukin-6 receptor alpha chain
  • CD126 antigen
  • IL-6R

General information

  • IL-6-R is localized in glandular epithelium throughout the menstrual cycle. [1]
  • The IL-6 receptor complex is expressed in different polarized epithelial cells such as liver hepatocytes and intestinal cells. [2]
  • FDCs in the follicular apical light zone expressed TGF-betaR II, GM-CSFRalpha, TNFR I, IL-1R II, IL-2Rbeta IL-4R and IL-6R [3]

Links to other resources

UniProt P08887
Ensembl ENST00000368485

Subunit information

long isoform

Sequence 
LAPRRCPAQ EVARGVLTS LPGDSVTLT 
CPGVEPEDN ATVHWVLRK PAAGSHPSR 
WAGMGRRLL LRSVQLHDS GNYSCYRAG 
RPAGTVHLL VDVPPEEPQ LSCFRKSPL 
SNVVCEWGP RSTPSLTTK AVLLVRKFQ 
NSPAEDFQE PCQYSQESQ KFSCQLAVP 
EGDSSFYIV SMCVASSVG SKFSKTQTF 
QGCGILQPD PPANITVTA VARNPRWLS 
VTWQDPHSW NSSFYRLRF ELRYRAERS 
KTFTTWMVK DLQHHCVIH DAWSGLRHV 
VQLRAQEEF GQGEWSEWS PEAMGTPWT 
ESRSPPAEN EVSTPMQAL TTNKDDDNI 
LFRDSANAT SLPVQDSSS VPLPTFLVA 
GGSLAFGTL LCIAIVLRF KKTWKLRAL 
KEGKTSMHP PYSLGQLVP ERPRPTPVL 
VPLISPPVS PSSLGSDNT SSHNRPDAR 
DPRSPYDIS NTDYFFPR
UniProt P08887-1

Binding hormones

  • interleukin 6

Anatomical structures with this receptor

  • cell_of_adrenal_gland_zona_fasciculata

    Influences

    • corticosterone
    • cortisol
    • cortisone

  • cell_of_adrenal_gland_zona_glomerulosa

  • cell_of_adrenal_gland_zona_reticularis

    Influences

    • dehydro-3-epiandrosterone
    • androstenedione
    • testosterone

  • cell_of_endometrium_of_uterus

  • hepatocyte

    Influences

    • positive hepcidin
      • Hepcidin mRNA expression can be induced in response to the inflammatory cytokine IL-6 (Interleukin-6). [4]
    • positive SAA1
    • positive fibrinogen
      • We determined the role of IL-6-receptor-gp130-Stat3 signaling in IL-6 activation of the γFBG promoter in liver and lung epithelial cells. [5]

  • monocyte

  • dendritic_cell_in_lymphoid_tissues_follicular

  • epithelial_cell_with_microvilli

    Influences

    • positive fibrinogen
      • We determined the role of IL-6-receptor-gp130-Stat3 signaling in IL-6 activation of the γFBG promoter in liver and lung epithelial cells. [5]

  • parathyroid_gland

    Influences

    • negative PTH
      • IL-6 decreases PTH secretion. [6]
Reference