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Details for receptor: IGF-1R

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EndoNet ID: ENR00865

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Synonyms

  • IGF-1R
  • IGF type 1 receptor
  • insulin-like growth factor type 1 receptor
  • IGF1R
  • IGF1 receptor

General information

  • The human fetal osteoblastic cell line ( hFOB/AR-6) expressed the type-I IGF receptor, but this was not regulated by 5-alpha-DHT. [1]
  • IGF-1R is an essential mediator of the intestinotropic actions of Glucagon-like peptide-2. [2]

Links to other resources

UniProt P08069
Ensembl ENST00000427922

Binding hormones

  • IGF-1B
  • IGF-1A
  • IGF-1
  • insulin
  • IGF

Anatomical structures with this receptor

  • adrenal_cortex

  • acidophil_somatotroph_cell_of_anterior_pituitary

    Influences

    • negative GH

    Induced phenotypes

    • cell growth
      • Insulin-like growth factor-1 mediates regulatory effects on cell growth by activation of IGF-1 receptor. [3]
    • positive regulation of cell proliferation
      • Insulin-like growth factor-1 stimulates proliferation of cells , required for sustained growth of many cells. [4]
    • negative regulation of apoptosis
      • Insulin-like growth factor-1 protects cells from apoptosis. [5]
    • transformation
      • Insulin-like growth factor-1 is required for transformation and maintenance of transformed state. [6]

  • osteoblast

  • chondrocyte

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • microvascularendothelial_cell

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Influences

    • positive annexin A2
      • Stimulation of insulin and IGF-1 receptors by insulin caused a temporary dissociation of annexin II from these receptors, which was accompanied by an increased amount of extracellular annexin II [7]

  • lung

    Influences

    • positive amphiregulin
      • Apoptosis inhibition by amphiregulin through an IGF1-dependent survival pathway in non-small cell lung cancer (NSCLC) cells: amphiregulin activates the IGF1 receptor that in turn induces the secretion of amphiregulin and IGF1. [8]
Reference