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Details for receptor: growth hormone receptor

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EndoNet ID: ENR00873

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Synonyms

  • GHR
  • growth hormone receptor
  • GHBP
  • growth hormone binding protein

General information

  • The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. [1]
  • GHBP is the extracellular domain of the GHR and binds about 45% of the circulating GH [2]

Links to other resources

UniProt P10912
Ensembl ENST00000357703

Subunit information

Isoform 1

Sequence 
MDLWQLLLT LALAGSSDA FSGSEATAA 
ILSRAPWSL QSVNPGLKT NSSKEPKFT 
KCRSPERET FSCHWTDEV HHGTKNLGP 
IQLFYTRRN TQEWTQEWK ECPDYVSAG 
ENSCYFNSS FTSIWIPYC IKLTSNGGT 
VDEKCFSVD EIVQPDPPI ALNWTLLNV 
SLTGIHADI QVRWEAPRN ADIQKGWMV 
LEYELQYKE VNETKWKMM DPILTTSVP 
VYSLKVDKE YEVRVRSKQ RNSGNYGEF 
SEVLYVTLP QMSQFTCEE DFYFPWLLI 
IIFGIFGLT VMLFVFLFS KQQRIKMLI 
LPPVPVPKI KGIDPDLLK EGKLEEVNT 
ILAIHDSYK PEFHSDDSW VEFIELDID 
EPDEKTEES DTDRLLSSD HEKSHSNLG 
VKDGDSGRT SCCEPDILE TDFNANDIH 
EGTSEVAQP QRLKGEADL LCLDQKNQN 
NSPYHDACP ATQQPSVIQ AEKNKPQPL 
PTEGAESTH QAAHIQLSN PSSLSNIDF 
YAQVSDITP AGSVVLSPG QKNKAGMSQ 
CDMHPEMVS LCQENFLMD NAYFCEADA 
KKCIPVAPH IKVESHIQP SLNQEDIYI 
TTESLTTAA GRPGTGEHV PGSEMPVPD 
YTSIHIVQS PQGLILNAT ALPLPDKEF 
LSSCGYVST DQLNKIMP

Isoform 2

Sequence 
MDLWQLLLT LALAGSSDA FSGSEATAA 
ILSRAPWSL QSVNPGLKT NSSKEPKFT 
KCRSPERET FSCHWTDEV HHGTKNLGP 
IQLFYTRRN TQEWTQEWK ECPDYVSAG 
ENSCYFNSS FTSIWIPYC IKLTSNGGT 
VDEKCFSVD EIVQPDPPI ALNWTLLNV 
SLTGIHADI QVRWEAPRN ADIQKGWMV 
LEYELQYKE VNETKWKMM DPILTTSVP 
VYSLKVDKE YEVRVRSKQ RNSGNY

Isoform 3

Sequence 
MDLWQLLLT LALAGSSDA FSGSEATAA 
ILSRAPWSL QSVNPGLKT NSSKEPKFT 
KCRSPERET FSCHWTDEV HHGTKNLGP 
IQLFYTRRN TQEWTQEWK ECPDYVSAG 
ENSCYFNSS FTSIWIPYC IKLTSNGGT 
VDEKCFSVD EIVQPDPPI ALNWTLLNV 
SLTGIHADI QVRWEAPRN ADIQKGWMV 
LEYELQYKE VNETKWKMM DPILTTSVP 
VYSLKVDKE YEVRVRSKQ RNSGNYGEF 
SEVLYVTLP QMSQFTCEE DFYFPWLLI 
IIFGIFGLT VMLFVFLFS KQQKEN

Isoform 4

Sequence 
MDLWQLLLT LALAGSSDA FSGSEDSSK 
EPKFTKCRS PERETFSCH WTDEVHHGT 
KNLGPIQLF YTRRNTQEW TQEWKECPD 
YVSAGENSC YFNSSFTSI WIPYCIKLT 
SNGGTVDEK CFSVDEIVQ PDPPIALNW 
TLLNVSLTG IHADIQVRW EAPRNADIQ 
KGWMVLEYE LQYKEVNET KWKMMDPIL 
TTSVPVYSL KVDKEYEVR VRSKQRNSG 
NYGEFSEVL YVTLPQMSQ FTCEEDFYF 
PWLLIIIFG IFGLTVMLF VFLFSKQQR 
IKMLILPPV PVPKIKGID PDLLKEGKL 
EEVNTILAI HDSYKPEFH SDDSWVEFI 
ELDIDEPDE KTEESDTDR LLSSDHEKS 
HSNLGVKDG DSGRTSCCE PDILETDFN 
ANDIHEGTS EVAQPQRLK GEADLLCLD 
QKNQNNSPY HDACPATQQ PSVIQAEKN 
KPQPLPTEG AESTHQAAH IQLSNPSSL 
SNIDFYAQV SDITPAGSV VLSPGQKNK 
AGMSQCDMH PEMVSLCQE NFLMDNAYF 
CEADAKKCI PVAPHIKVE SHIQPSLNQ 
EDIYITTES LTTAAGRPG TGEHVPGSE 
MPVPDYTSI HIVQSPQGL ILNATALPL 
PDKEFLSSC GYVSTDQLN KIMP

Binding hormones

  • CSH1
    • HGHRd3 binds all three of the placentally expressed members of the GH/Prl gene family (hGH-V, hCS, and Prl). [3]
  • PRL
    • Human GHR binds Human PRL [3]
  • GH-2
  • GH
    (trough: blood
    )
  • CSH2
    • HGHRd3 binds all three of the placentally expressed members of the GH/Prl gene family (hGH-V, hCS, and Prl). [3]

Anatomical structures with this receptor

  • fat_cell

    Influences

    • positive leptin

  • chondrocyte

  • hepatocyte

  • pituitary_gland_of_diencephalon

    Induced phenotypes

    • dwarfism
      • In humans, that lack GH or not have a functional GHR, dwarfism is always observed. [4]
      • Laron-like dwarfism [5]
    • Acromegaly due to pituitary adenoma
      • Dysregulated growth hormone hypersecretion is usually caused by a GH-secreting pituitary adenoma and leads to acromegaly. [6]

  • thymic_epithelial_cell

    Influences

    • positive Thymulin
      • In vitro, human GH can stimulate thymulin release from TEC lines. [7]
      • It is likely that these effects of GH are mediated, at least in part, by insulin-like growth factor 1 (IGF-1) as suggested by the fact that the GH-induced enhancement of thymulin production could be prevented by previous treatment with antibodies against IGF-1 or IGF-1 receptor. [7]
    • TEC lines are known to possess specific receptors for GH. [8]

  • skeleton_muscle

    Induced phenotypes

    • Laron syndrome
      • In the majority of GHI patients, a genetic defect in the GH receptor gene leading to a functionless receptor is present. [9]
Reference