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Details for receptor: CSF2RB

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  • General information
  • Subunits
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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00882

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • beta-c
  • CSF2RB
  • GM-CSF/IL-3/IL-5 receptor common beta-chain
  • CD131 antigen
  • CDw131

General information

  • IL-3, IL-5, and GM-CSF exert overlapping functions in eosinophils via a shared receptor beta-chain. [1]
  • The human beta chain alone does not bind either of the three cytokines (IL3, IL5, GM-CSF). [2]
  • High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. [3]

Links to other resources

UniProt P32927
Ensembl ENST00000421539

Subunit information

Sequence 
WERSLAGAE ETIPLQTLR CYNDYTSHI 
TCRWADTQD AQRLVNVTL IRRVNEDLL 
EPVSCDLSD DMPWSACPH PRCVPRRCV 
IPCQSFVVT DVDYFSFQP DRPLGTRLT 
VTLTQHVQP PEPRDLQIS TDQDHFLLT 
WSVALGSPQ SHWLSPGDL EFEVVYKRL 
QDSWEDAAI LLSNTSQAT LGPEHLMPS 
STYVARVRT RLAPGSRLS GRPSKWSPE 
VCWDSQPGD EAQPQNLEC FFDGAAVLS 
CSWEVRKEV ASSVSFGLF YKPSPDAGE 
EECSPVLRE GLGSLHTRH HCQIPVPDP 
ATHGQYIVS VQPRRAEKH IKSSVNIQM 
APPSLNVTK DGDSYSLRW ETMKMRYEH 
IDHTFEIQY RKDTATWKD SKTETLQNA 
HSMALPALE PSTRYWARV RVRTSRTGY 
NGIWSEWSE ARSWDTESV LPMWVLALI 
VIFLTIAVL LALRFCGIY GYRLRRKWE 
EKIPNPSKS HLFQNGSAE LWPPGSMSA 
FTSGSPPHQ GPWGSRFPE LEGVFPVGF 
GDSEVSPLT IEDPKHVCD PPSGPDTTP 
AASDLPTEQ PPSPQPGPP AASHTPEKQ 
ASSFDFNGP YLGPPHSRS LPDILGQPE 
PPQEGGSQK SPPPGSLEY LCLPAGGQV 
QLVPLAQAM GPGQAVEVE RRPSQGAAG 
SPSLESGGG PAPPALGPR VGGQDQKDS 
PVAIPMSSG DTEDPGVAS GYVSSADLV 
FTPNSGASS VSLVPSLGL PSDQTPSLC 
PGLASGPPG APGPVKSGF EGYVELPPI 
EGRSPRSPR NNPVPPEAK SPVLNPGER 
PADVSPTSP QPEGLLVLQ QVGDYCFLP 
GLGPGPLSL RSKPSSPGP GPEIKNLDQ 
AFQVKKPPG QAVPQVPVI QLFKALKQQ 
DYLSLPPWE VNKPGEVC

Binding hormones

  • GM-CSF
  • IL-3
  • IL-5

Anatomical structures with this receptor

  • eosinophil_granulocyte

Reference