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Details for receptor: activin receptor type I

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EndoNet ID: ENR00884

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Synonyms

  • ACTR-I
  • activin receptor type I
  • activin receptor-like kinase 2
  • ACVR1
  • ACVRLK2
  • ALK-2
  • serine/threonine-protein kinase receptor R1
  • SKR1
  • TGF-beta superfamily receptor family type I
  • TSR-I

General information

  • Enzyme classification: EC 2.7.1.37.
  • Keywords: Transmembrane, Glycoprotein, Transferase, Receptor, ATP-binding, Serine/threonine-protein kinase. [1]
  • Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. [2]

Links to other resources

UniProt Q04771
Ensembl ENST00000440523

Subunit information

Sequence 
MEDEKPKVN PKLYMCVCE GLSCGNEDH 
CEGQQCFSS LSINDGFHV YQKGCFQVY 
EQGKMTCKT PPSPGQAVE CCQGDWCNR 
NITAQLPTK GKSFPGTQN FHLEVGLII 
LSVVFAVCL LACLLGVAL RKFKRRNQE 
RLNPRDVEY GTIEGLITT NVGDSTLAD 
LLDHSCTSG SGSGLPFLV QRTVARQIT 
LLECVGKGR YGEVWRGSW QGENVAVKI 
FSSRDEKSW FRETELYNT VMLRHENIL 
GFIASDMTS RHSSTQLWL ITHYHEMGS 
LYDYLQLTT LDTVSCLRI VLSIASGLA 
HLHIEIFGT QGKPAIAHR DLKSKNILV 
KKNGQCCIA DLGLAVMHS QSTNQLDVG 
NNPRVGTKR YMAPEVLDE TIQVDCFDS 
YKRVDIWAF GLVLWEVAR RMVSNGIVE 
DYKPPFYDV VPNDPSFED MRKVVCVDQ 
QRPNIPNRW FSDPTLTSL AKLMKECWY 
QNPSARLTA LRIKKTLTK IDNSLDKLK 
TDC

Binding hormones

  • AMH
  • BMP6
    • BMP-6 strongly bound to activin receptor-like kinase (ALK)-2 (also termed ActR-I), together with type II receptors, i.e. BMP type II receptor (BMPR-II) and activin type II receptor (ActR-II). [3]

Anatomical structures with this receptor

  • muscle

  • pancreas

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • fibroblast

  • chondrocyte

    Induced phenotypes

    • fibrodysplasia ossificans progressiva (FOP)
      • Constitutive activation of ACVR1 induces alkaline phosphatase activity in C2C12 cells, upregulates BMP4, downregulates BMP antagonists, expands cartilage elements, induces ectopic chondrogenesis and stimulates joint fusions and is the underlying cause of the ectopic chondrogenesis, osteogenesis and joint fusions seen in FOP. [4]
Reference