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Details for receptor: activin receptor type 2B

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EndoNet ID: ENR00885

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Synonyms

  • ACTR-IIB
  • activin receptor type 2B
  • ActRIIB

General information

  • Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. [1]

Links to other resources

UniProt Q13705
Ensembl ENST00000352511

Subunit information

Sequence 
SGRGEAETR ECIYYNANW ELERTNQSG 
LERCEGEQD KRLHCYASW ANSSGTIEL 
VKKGCWLDD FNCYDRQEC VATEENPQV 
YFCCCEGNF CNERFTHLP EAGGPEVTY 
EPPPTAPTL LTVLAYSLL PIGGLSLIV 
LLAFWMYRH RKPPYGHVD IHEDPGPPP 
PSPLVGLKP LQLLEIKAR GRFGCVWKA 
QLMNDFVAV KIFPLQDKQ SWQSEREIF 
STPGMKHEN LLQFIAAEK RGSNLEVEL 
WLITAFHDK GSLTDYLKG NIITWNELC 
HVAETMSRG LSYLHEDVP WCRGEGHKP 
SIAHRDFKS KNVLLKSDL TAVLADFGL 
AVRFEPGKP PGDTHGQVG TRRYMAPEV 
LEGAINFQR DAFLRIDMY AMGLVLWEL 
VSRCKAADG PVDEYMLPF EEEIGQHPS 
LEELQEVVV HKKMRPTIK DHWLKHPGL 
AQLCVTIEE CWDHDAEAR LSAGCVEER 
VSLIRRSVN GTTSDCLVS LVTSVTNVD 
LPPKESSI

Binding hormones

  • GDF-8
    • Myostatin (=GDF-8) binds the type IIB activin receptor. [2]
  • BMP6
    • BMP-6 strongly bound to activin receptor-like kinase (ALK)-2 (also termed ActR-I), together with type II receptors, i.e. BMP type II receptor (BMPR-II) and activin type II receptor (ActR-II). [3]

Anatomical structures with this receptor

  • cell_of_endometrium_of_uterus

    Induced phenotypes

    • cell differentiation
      • Human endometrium expresses activin A recpetor type I and type II. Thereby, it is a target for activin A, which stimulates stromal cell differentiation along with the expression and secretion of markers of endometrial receptivity. [4]

  • pancreatic_islets

    Induced phenotypes

    • embryonic digestive tract development
      • Activins, members of the transforming growth factor-β (TGF-β) superfamily, govern embryonic axial patterning. [5]
      • ActRIIB-mediated signaling controls both AP pattern of the axial skeleton and lateral asymmetry of heart and lungs. [6]
      • Both ActRIIA and ActRIIB are expressed in the primordia of foregut organs, including lungs, stomach, intestines, and pancreas. [7]
      • Type II activin receptors are crucial for normal development of many foregut organs, and these receptors have a particularly critical role in development and function of the endocrine pancreas. [8]
    • In adult mice, both ActRIIA and ActRIIB are expressed in pancreatic islet cells. [9]
Reference