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Details for receptor: trkA

EndoNet ID: ENR00897

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Synonyms

  • trkA
  • nerve growth factor tyrosine kinase receptor
  • Ntrk1
  • p140-TrkA
  • TRK1-transforming tyrosine kinase protein
  • Neurotrophic tyrosine kinase receptor type 1
  • High affinity nerve growth factor receptor

General information

Links to other resources

UniProt P04629
Ensembl ENST00000392302

Binding hormones

  • NGF

Anatomical structures with this receptor

  • dorsal_root_ganglion

    Induced phenotypes

    • thermoception
      • Neuroanatomical examinatio of the PNS of mice lacking trkA revealed extensive neuronal cell loss in trigeminal, dorsal root, and sympathetic ganglia. [1]
      • Mice lacking the trkA exhibit deficiencies in thermoception. [2]
      • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [2]
Reference