Status
Please wait ...

Details for receptor: calcitonin receptor

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00898

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • calcitonin receptor
  • CT-R
  • CTR

General information

  • Binding sites at area postrema appear to be composed of CTa + RAMP3 [amylin3 (a) receptors]. [1]
  • The CTa (shorter form) calcitonin receptor, dimerized with RAMP1 [amylin 1 (a) receptor], appears to represent binding sites at the nucleus accumbens and the subfornical organ. [1]
  • The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. [2]

Links to other resources

UniProt P30988
Ensembl ENST00000426151

Subunit information

P30988-1

Sequence 
AFSNQTYPT IEPKPFLYV VGRKKMMDA 
QYKCYDRMQ QLPAYQGEG PYCNRTWDG 
WLCWDDTPA GVLSYQFCP DYFPDFDPS 
EKVTKYCDE KGVWFKHPE NNRTWSNYT 
MCNAFTPEK LKNAYVLYY LAIVGHSLS 
IFTLVISLG IFVFFRKLT TIFPLNWKY 
RKALSLGCQ RVTLHKNMF LTYILNSMI 
IIIHLVEVV PNGELVRRD PVSCKILHF 
FHQYMMACN YFWMLCEGI YLHTLIVVA 
VFTEKQRLR WYYLLGWGF PLVPTTIHA 
ITRAVYFND NCWLSVETH LLYIIHGPV 
MAALVVNFF FLLNIVRVL VTKMRETHE 
AESHMYLKA VKATMILVP LLGIQFVVF 
PWRPSNKML GKIYDYVMH SLIHFQGFF 
VATIYCFCN NEVQTTVKR QWAQFKIQW 
NQRWGRRPS NRSARAAAA AAEAGDIPI 
YICHQEPRN EPANNQGEE SAEIIPLNI 
IEQESSA

Binding hormones

  • calcitonin
    (trough: blood
    )
    • Calcitonin acts directly on cells of the osteoclast lineage to suppress the differentiation and function of these cells as well as to accelerate their apoptosis. [3]
  • intestinal peptide PHM-27
  • IAPP
  • CGRP2

Anatomical structures with this receptor

  • osteoclast

    Induced phenotypes

    • osteoporosis
      • The discovery that calcitonin is a selective inhibitor of osteoclastic activity more than 40 years ago led to the concept that calcitonin deficiency might be the cause of osteoporosis and that its administration might be the cure. [4]

  • nucleus_accumbens

  • area_postrema_of_pons

Reference