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Details for receptor: progesterone receptor A

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EndoNet ID: ENR00906

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Synonyms

  • PR A
  • progesterone receptor A
  • NR3C3a

General information

  • PRA was detected in eccrine sweat glands, sebaceous glands, epidermis and outer root sheath of hair follicles. [1]
  • GnRH neurons (GT 1-7) express receptors for progesterone (progesterone receptor A). [2]
  • Progesterone receptors A and B differentially modulate corticotropin-releasing hormone. [3]
  • Overexpression of PR-A or glucocorticoid receptor resulted in a decrease in CRH promoter activity. [3]

Links to other resources

UniProt P06401-2
Ensembl ENST00000325455

Binding hormones

  • progesterone
    • In vertebrates and humans, the biological activity of progesterone is mediated by two progesterone receptor proteins PR-A and PR-B. [4]

Anatomical structures with this receptor

  • arcuate_nucleus_of_hypothalamus

    Influences

    • negative GnRH-I

  • eccrine_sweat_glands

  • sebaceous_glands

    Induced phenotypes

    • sebaceous gland development
      • Progesterone could increase the size of sebaceous glands in spayed rats. [5]
      • But this hormone is not responsible for maintaining sebaceous gland secretion. [6]

  • epidermis

  • hair_follicle

Reference