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Details for receptor: M5

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EndoNet ID: ENR00917

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Synonyms

  • muscarinic acetylcholine receptor M5
  • CHRM5
  • M5

General information

  • M2, M4 and M5 muscarinic receptor subtypes bound in human corneal epithelium and endothelium. No binding was found for antibodies to M1 and M3 muscarinic receptor subtypes. [1]

Links to other resources

UniProt P08912
Ensembl ENST00000383263

Subunit information

Sequence 
MEGDSYHNA TTVNGTPVN HQPLERHRL 
WEVITIAAV TAVVSLITI VGNVLVMIS 
FKVNSQLKT VNNYYLLSL ACADLIIGI 
FSMNLYTTY ILMGRWALG SLACDLWLA 
LDYVASNAS VMNLLVISF DRYFSITRP 
LTYRAKRTP KRAGIMIGL AWLISFILW 
APAILCWQY LVGKRTVPL DECQIQFLS 
EPTITFGTA IAAFYIPVS VMTILYCRI 
YRETEKRTK DLADLQGSD SVTKAEKRK 
PAHRALFRS CLRCPRPTL AQRERNQAS 
WSSSRRSTS TTGKPSQAT GPSANWAKA 
EQLTTCSSY PSSEDEDKP ATDPVLQVV 
YKSQGKESP GEEFSAEET EETFVKAET 
EKSDYDTPN YLLSPAAAH RPKSQKCVA 
YKFRLVVKA DGNQETNNG CHKVKIMPC 
PFPVAKEPS TKGLNPNPS HQMTKRKRV 
VLVKERKAA QTLSAILLA FIITWTPYN 
IMVLVSTFC DKCVPVTLW HLGYWLCYV 
NSTVNPICY ALCNRTFRK TFKMLLLCR 
WKKKKVEEK LYWQGNSKL P

Binding hormones

  • acetylcholine

Anatomical structures with this receptor

  • corneal_endothelial_cell

  • corneal_endothelial_cell

  • adrenal_medulla

    Influences

    • positive acetylcholine
      • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [2]
Reference