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Details for receptor: sst3

EndoNet ID: ENR00920

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  • sst(3)
  • sst3
  • somatostatin receptor 3
  • SSTR3

General information

  • SSTR3 was detected in occasional alpha-cells, and SSTR4 was absent. [1]
  • SSTR3 and SSTR4 were relatively poorly expressed in beta cells. [1]
  • SSTR1-3 were colocalized in only a few delta-cells, and SSTR4 was absent. [1]
  • Belongs to the seven transmembrane domain receptor family. [2]

Links to other resources

UniProt P32745
Ensembl ENST00000402501

Binding hormones

  • somatostatin
    • Works better with SST-28 than with SST-14.
  • somatostatin-14
  • somatostatin-28
  • cortistatin
    • CST-17 and its rodent homologue CST-14 both bind nonselectively and with nanomolar affinities to all five somatostatin receptor subtypes in vitro. [3]

Anatomical structures with this receptor

  • pituitary_gland_of_diencephalon

  • brain

  • stomach

  • alpha_cell_of_islet_of_Langerhans


    • negative glucagon
  • D_cell


    • negative somatostatin
  • beta_cell_of_islet_of_Langerhans


    • negative insulin