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Details for receptor: neurotensin receptor type 1

EndoNet ID: ENR00923

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  • NT-R1
  • neurotensin receptor type 1

General information

  • In peripheral tissues, the highest levels of NTR mRNA were detected in the colon, followed by the liver, and then duodenum and pancreas. [1]
  • Nucleus caudatus, the putamen and the nucleus accumbens contain very high to high levels of neurotensin receptor binding sites. [2]
  • Neurotensin and its high affinity receptor (NTSR1) localise within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems and it is now clear that neurotensin can selectively modulate dopaminergic neurotransmission. [3]

Links to other resources

UniProt P30989
Ensembl ENST00000370501

Binding hormones

  • NT
    • Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. [4]
  • neuromedin N
    • NTSR1 also binds the NTS-related hexapeptide neuromedin N. [5]

Anatomical structures with this receptor

  • caudate_nucleus

  • putamen

  • nucleus_accumbens

  • colon

  • duodenum

    Induced phenotypes

    • lipid digestion
  • pancreas

  • stomach

    Induced phenotypes

    • decrease in gastric acid secretion
  • brain

    Induced phenotypes

    • eating behavior
      • NTR1 is involved in control of food consumption and body weight, but not in Neurotensin-induced analgesia. [6]
  • central_nerve_system_element

    Induced phenotypes

    • modulation of dopaminergic transmission
    • pituitary hormone release
      • Central administration for Neurotensin: modulation of pituitary hormone release. [7]
    • eating behavior
      • inhibition of food intake