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Details for receptor: EGFR isoform a

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  • General information
  • Subunits
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  • General information
  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00930

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Synonyms

  • EGFR isoform a
  • ErbB1
  • epidermal growth factor receptor isoform a
  • human EGF receptor isoform a
  • HER1

General information

  • Activation of ErbB receptors is important for the regulation of cell proliferation, differentiation, and survival. Binding of specific ligand to one of the ErbB receptors triggers the formation of specific receptor homo- and heterodimers, with ErbB2 beeing the preferred signaling partner. [1]
  • Both an increase in intracellular calcium and activation of PKC lead to activation of an extracellular metalloproteinase that acts on the membrane bound precursors of EGF-receptor ligands including HB-EGF, amphiregulin and TGF-alpha. [2]
  • All EGFR ligands are made as membrane-anchored precursors that can be proteolytically released from cells. [3]
  • Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. [4]
  • Hepatocytes display only a low level of the LDL-R and EGF-R, but cocultured with LSECs show a high level of LDL-R and EGF-R. [5]

Links to other resources

UniProt P00533
Ensembl ENST00000455089

Subunit information

Sequence 
LEEKKVCQG TSNKLTQLG TFEDHFLSL 
QRMFNNCEV VLGNLEITY VQRNYDLSF 
LKTIQEVAG YVLIALNTV ERIPLENLQ 
IIRGNMYYE NSYALAVLS NYDANKTGL 
KELPMRNLQ EILHGAVRF SNNPALCNV 
ESIQWRDIV SSDFLSNMS MDFQNHLGS 
CQKCDPSCP NGSCWGAGE ENCQKLTKI 
ICAQQCSGR CRGKSPSDC CHNQCAAGC 
TGPRESDCL VCRKFRDEA TCKDTCPPL 
MLYNPTTYQ MDVNPEGKY SFGATCVKK 
CPRNYVVTD HGSCVRACG ADSYEMEED 
GVRKCKKCE GPCRKVCNG IGIGEFKDS 
LSINATNIK HFKNCTSIS GDLHILPVA 
FRGDSFTHT PPLDPQELD ILKTVKEIT 
GFLLIQAWP ENRTDLHAF ENLEIIRGR 
TKQHGQFSL AVVSLNITS LGLRSLKEI 
SDGDVIISG NKNLCYANT INWKKLFGT 
SGQKTKIIS NRGENSCKA TGQVCHALC 
SPEGCWGPE PRDCVSCRN VSRGRECVD 
KCNLLEGEP REFVENSEC IQCHPECLP 
QAMNITCTG RGPDNCIQC AHYIDGPHC 
VKTCPAGVM GENNTLVWK YADAGHVCH 
LCHPNCTYG CTGPGLEGC PTNGPKIPS 
IATGMVGAL LLLLVVALG IGLFMRRRH 
IVRKRTLRR LLQERELVE PLTPSGEAP 
NQALLRILK ETEFKKIKV LGSGAFGTV 
YKGLWIPEG EKVKIPVAI KELREATSP 
KANKEILDE AYVMASVDN PHVCRLLGI 
CLTSTVQLI TQLMPFGCL LDYVREHKD 
NIGSQYLLN WCVQIAKGM NYLEDRRLV 
HRDLAARNV LVKTPQHVK ITDFGLAKL 
LGAEEKEYH AEGGKVPIK WMALESILH 
RIYTHQSDV WSYGVTVWE LMTFGSKPY 
DGIPASEIS SILEKGERL PQPPICTID 
VYMIMVKCW MIDADSRPK FRELIIEFS 
KMARDPQRY LVIQGDERM HLPSPTDSN 
FYRALMDEE DMDDVVDAD EYLIPQQGF 
FSSPSTSRT PLLSSLSAT SNNSTVACI 
DRNGLQSCP IKEDSFLQR YSSDPTGAL 
TEDSIDDTF LPVPEYINQ SVPKRPAGS 
VQNPVYHNQ PLNPAPSRD PHYQDPHST 
AVGNPEYLN TVQPTCVNS TFDSPAHWA 
QKGSHQISL DNPDYQQDF FPKEAKPNG 
IFKGSTAEN AEYLRVAPQ SSEFIGA

Binding hormones

  • EGF
  • EPR
    • EGF, HB-EGF, amphiregulin, betacellulin, TGF-alpha and epiregulin are immunoreactive EGFR ligands. [6]
  • amphiregulin
    • Similar to EGF, AR binds and signals through the EGF receptor (EGFR/Erbb1). [7]
  • TGF-alpha
  • betacellulin
  • HB-EGF

Anatomical structures with this receptor

  • placenta

  • hepatocyte

    Influences

    • positive IL-1 alpha
      • Induced IL-1alpha release from hepatocyte is contingent on both TNF and autocrine TGF-alpha. [8]
    • positive IL-1 beta
      • Induced IL-1alpha release from hepatocyte is contingent on both TNF and autocrine TGF-alpha. [8]

  • neutrophil_granulocyte

    Influences

    • positive IL-8
      • EGF alone was able to prime CD11b expression and IL-8 production by PMN. [9]

  • epithelial_cell

  • epithelial_cell_with_microvilli

    Influences

    • positive mucin-2
      • PAFR transduces the signal to EGFR via ADAM10-dependent proteolysis of transmembrane HB-EGF. [6]

  • lipocyte_of_liver

    Induced phenotypes

    • positive regulation of cell proliferation and apotosis
      • In quiescent HSC, hydrophobic bile acids activate the EGFR, and this can couple to both cell proliferation and apoptosis, depending on the JNK signaling. Therefore, JNK act as a switch between bile acid-induced proliferation and apoptosis in HSC. [10]

  • G_cell

    Influences

    • positive gastrin
      • Activation of the canonical MAPK pathway by EGF stimulates gastrin gene expression via phosphorylation of Sp1. [2]

  • digestive_system

Reference