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Details for receptor: TLR1

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EndoNet ID: ENR00931

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Synonyms

  • toll-like receptor 1
  • TLR1
  • CD281 antigen
  • TIL
  • toll/interleukin-1 receptor-like protein

General information

  • TLR1 was expressed in all leukocytes examined, including monocytes, polymorphonuclear leukocytes, T and B cells, and NK cells. [1]
  • CF and non-CF airway epithelial cells(a human bronchial epithelial cell line) express TLR1–6, TLR9, and CD14. [2]
  • Cooperates with TLR2 and modulates the response to microbial constituents. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [3]
  • Epithelial cells derived from normal human vagina, ectocervix, and endocervix expressed mRNA for TLR1, -2, -3, -5, and -6. [4]
  • Normal human cholangiocytes express all known TLRs. [5]

Links to other resources

UniProt Q15399
Ensembl ENST00000308979

Subunit information

Sequence 
SEFLVDRSK NGLIHVPKD LSQKTTILN 
ISQNYISEL WTSDILSLS KLRILIISH 
NRIQYLDIS VFKFNQELE YLDLSHNKL 
VKISCHPTV NLKHLDLSF NAFDALPIC 
KEFGNMSQL KFLGLSTTH LEKSSVLPI 
AHLNISKVL LVLGETYGE KEDPEGLQD 
FNTESLHIV FPTNKEFHF ILDVSVKTV 
ANLELSNIK CVLEDNKCS YFLSILAKL 
QTNPKLSSL TLNNIETTW NSFIRILQL 
VWHTTVWYF SISNVKLQG QLDFRDFDY 
SGTSLKALS IHQVVSDVF GFPQSYIYE 
IFSNMNIKN FTVSGTRMV HMLCPSKIS 
PFLHLDFSN NLLTDTVFE NCGHLTELE 
TLILQMNQL KELSKIAEM TTQMKSLQQ 
LDISQNSVS YDEKKGDCS WTKSLLSLN 
MSSNILTDT IFRCLPPRI KVLDLHSNK 
IKSIPKQVV KLEALQELN VAFNSLTDL 
PGCGSFSSL SVLIIDHNS VSHPSADFF 
QSCQKMRSI KAGDNPFQC TCELGEFVK 
NIDQVSSEV LEGWPDSYK CDYPESYRG 
TLLKDFHMS ELSCNITLL IVTIVATML 
VLAVTVTSL CIYLDLPWY LRMVCQWTQ 
TRRRARNIP LEELQRNLQ FHAFISYSG 
HDSFWVKNE LLPNLEKEG MQICLHERN 
FVPGKSIVE NIITCIEKS YKSIFVLSP 
NFVQSEWCH YELYFAHHN LFHEGSNSL 
ILILLEPIP QYSIPSSYH KLKSLMARR 
TYLEWPKEK SKRGLFWAN LRAAINIKL 
TEQAKK

Binding hormones

  • BD-3
    • Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. [6]

Anatomical structures with this receptor

  • monocyte

    Induced phenotypes

    • monocyte activation
      • We provide evidence that hBD-3 activates cells in a TLR1- and TLR2-dependent manner. [7]
      • hBD-3 induces activation of monocytes and mDCs, but not pDCs or B cells, is consistent with the expected pattern of TLR2 and TLR1 expression on these cells. [7]

  • B-lymphocyte

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • epithelial_cell_with_microvilli

  • vaginal_mucosa

  • cervical_canal_of_uterus

  • cholangiocyte

  • leukocyte

  • bronchial_epithelial_cell

  • T-lymphocyte

  • macrophage

    Influences

    • positive IL-1 beta
      • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [8]
Reference