Status
Please wait ...

Details for receptor: GHS-R1

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00936

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • GHS-R1
  • growth hormone secretagogue receptor type 1
  • ghrelin receptor
  • GHS receptor
  • GH secretagogues receptor

General information

  • GSH-R are concentrated in the hypothalamus-pituitary unit. [1]
  • GHSR on pituitary gland and hypothalamus [2]
  • GHSR is constitutivly active [3]
  • ...ghrelin receptors can be retained in the endoplasmatic reticulum by heterodimerization with GHS-R1b... [4]

Links to other resources

UniProt Q92847
Ensembl ENST00000427970

Subunit information

Isoform 1A

  • 1a excises an intron and encodes the functional protein (NCBI 2693)
Sequence 
MWNATPSEE PGFNLTLAD LDWDASPGN 
DSLGDELLQ LFPAPLLAG VTATCVALF 
VVGIAGNLL TMLVVSRFR ELRTTTNLY 
LSSMAFSDL LIFLCMPLD LVRLWQYRP 
WNFGDLLCK LFQFVSESC TYATVLTIT 
ALSVERYFA ICFPLRAKV VVTKGRVKL 
VIFVIWAVA FCSAGPIFV LVGVEHENG 
TDPWDTNEC RPTEFAVRS GLLTVMVWV 
SSIFFFLPV FCLTVLYSL IGRKLWRRR 
RGDAVVGAS LRDQNHKQT VKMLAVVVF 
AFILCWLPF HVGRYLFSK SFEPGSLEI 
AQISQYCNL VSFVLFYLS AAINPILYN 
IMSKKYRVA VFRLLGFEP FSQRKLSTL 
KDESSRAWT ESSINT
UniProt Q92847-1

Isoform 1B

  • 1B retains the intron and does not function as receptor for ghrelin (NCBI 2693)
  • truncated ghrelin receptor peptide GHS-R1b...has a dominant-negative effect on ghrelin receptor function. [4]
Sequence 
MWNATPSEE PGFNLTLAD LDWDASPGN 
DSLGDELLQ LFPAPLLAG VTATCVALF 
VVGIAGNLL TMLVVSRFR ELRTTTNLY 
LSSMAFSDL LIFLCMPLD LVRLWQYRP 
WNFGDLLCK LFQFVSESC TYATVLTIT 
ALSVERYFA ICFPLRAKV VVTKGRVKL 
VIFVIWAVA FCSAGPIFV LVGVEHENG 
TDPWDTNEC RPTEFAVRS GLLTVMVWV 
SSIFFFLPV FCLTVLYSL IGRKLWRRR 
RGDAVVGAS LRDQNHKQT VKMLGGSQR 
ALRLSLAGP ILSLCLLPS L
UniProt Q92847-2

Binding hormones

  • ghrelin
    (trough: blood
    )

Anatomical structures with this receptor

  • acidophil_somatotroph_cell_of_anterior_pituitary

    Influences

    • positive GH

  • thyroid_gland

  • arcuate_nucleus_of_hypothalamus

    Influences

    • positive AGRP
    • positive NPY
    • negative POMC
      • Ghrelin inhibits POMC neurons of the Hypothalamus

    Induced phenotypes

    • positive regulation of appetite
      • Ghrelin transduces an appetite-stimulatory signal from peripheral tissues to central nervous system [5]
      • Ghrelin acts in harmony with appetite-stimulating signals from peripheral organs and stimulate food intake [6]
    • regulation of feeding behavior
      • Ghrelin activates feeding through fatty acid oxidation and free radical buffering in the NPY/Agrp neurons of the ARC. Ghrelin induces feeding by the activation of its receptor, the G-protein-coupled growth hormone secretagogue receptor, in the NPY/Agrp neurons, which induces a rapid increase in the firing rate of these cells. [7]
    • Short stature

  • pituitary_gland_of_diencephalon

    Influences

    • positive PRL
      • ...stimulatory effect of CST on PRL release is exerted through a receptor not shared by SST...it has been reported that CST(...)binds with high affinity to GHS-R1a(...) which in turn is known to stimulate PRL secretion [8]

    Induced phenotypes

    • Short stature

  • hypothalamus

    Influences

    • positive GH
      • GHS-R 1a mediates the classical GH-releasing effect [9]

    Induced phenotypes

    • memory performance
      • Ghrelin is involved in memory performance. [10]
    • positive regulation of appetite
      • High ghrelin levels lead on the level of the hypothlamus to increased food intake [11]
    • Short stature
Reference