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Details for receptor: GHS-R1a

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  • General information
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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00939

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Synonyms

  • GHS-R1a
  • growth hormone secretagogue receptor isoform 1a
  • ghrelin receptor

General information

Links to other resources

UniProt Q92847-1
Ensembl ENST00000427970

Subunit information

Sequence 
MWNATPSEE PGFNLTLAD LDWDASPGN 
DSLGDELLQ LFPAPLLAG VTATCVALF 
VVGIAGNLL TMLVVSRFR ELRTTTNLY 
LSSMAFSDL LIFLCMPLD LVRLWQYRP 
WNFGDLLCK LFQFVSESC TYATVLTIT 
ALSVERYFA ICFPLRAKV VVTKGRVKL 
VIFVIWAVA FCSAGPIFV LVGVEHENG 
TDPWDTNEC RPTEFAVRS GLLTVMVWV 
SSIFFFLPV FCLTVLYSL IGRKLWRRR 
RGDAVVGAS LRDQNHKQT VKMLAVVVF 
AFILCWLPF HVGRYLFSK SFEPGSLEI 
AQISQYCNL VSFVLFYLS AAINPILYN 
IMSKKYRVA VFRLLGFEP FSQRKLSTL 
KDESSRAWT ESSINT

Binding hormones

  • cortistatin
    • Cortistatin (CST)... binds all SRIF receptors and also GHS-R. [1]
  • ghrelin

Anatomical structures with this receptor

  • hypothalamus

    Influences

    • positive GH
      • Ghrelin is an endogenous ligand for the growth hormone secretagogue type 1a receptor (GHS-R1a), the functionally active form of GHS-R, and stimulates feeding and growth hormone secretion. [2]
      • Ghrelin stimulates GH release by activating both AC and PLC pathways, either by binding to distinct binding pockets of GHS-R, and/or enabling dimeric GHS-R forms, or by binding and activating an alternate, different receptor. [3]
    • positive orexin-A
      • Ghrelin stimulates the secretion of orexin [4]
Reference