Status
Please wait ...

Details for receptor: gonadotropin-releasing hormone receptor

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00942

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • gonadotropin-releasing hormone receptor isoform 1
  • gonadotropin-releasing hormone receptor
  • GnRH-R
  • GNRHR
  • LHRHR

General information

  • Two isoforms are known: GnRH-R1 and GnRH-R2. [1]
  • Both isoforms are members of the G protein-coupled receptor family of proteins and function in the inositol phosphate-signaling pathway. [1]

Links to other resources

UniProt P30968
Ensembl ENST00000420975

Subunit information

GNRHR

Sequence 
MANSASPEQ NQNHCSAIN NSIPLMQGN 
LPTLTLSGK IRVTVTFFL FLLSATFNA 
SFLLKLQKW TQKKEKGKK LSRMKLLLK 
HLTLANLLE TLIVMPLDG MWNITVQWY 
AGELLCKVL SYLKLFSMY APAFMMVVI 
SLDRSLAIT RPLALKSNS KVGQSMVGL 
AWILSSVFA GPQLYIFRM IHLADSSGQ 
TKVFSQCVT HCSFSQWWH QAFYNFFTF 
SCLFIIPLF IMLICNAKI IFTLTRVLH 
QDPHELQLN QSKNNIPRA RLKTLKMTV 
AFATSFTVC WTPYYVLGI WYWFDPEML 
NRLSDPVNH FFFLFAFLN PCFDPLIYG 
YFSL

Binding hormones

  • GnRH-I

Anatomical structures with this receptor

  • basophil_gonadotroph_cell_of_anterior_pituitary_FSH

    Influences

    • positive LH
      • Correlation between the GnRH-stimulated release of both LH and SgII in vitro. [2]
      • Co-localization and co-release of LH and SgII in vivo. [3]
      • SgII plays an important role in the regulated secretion of LH. [4]
      • Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [4]
      • LH released in response to GnRH is co-released with SgII via a regulated secretory pathway and that the activinstimulated LH release is probably via a constitutive, SgII-granule-independent pathway. [4]
    • positive FSH
    • positive secretoneurin
      • Co-localization and co-release of LH and SgII in vivo. [3]
      • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [2]
    • positive secretogranin-2
      • Co-localization and co-release of LH and SgII in vivo. [3]
      • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [2]
    • positive FSH
      • GnRH requires the presence of activin in order to exert its action. [4]
    • positive chromogranin A
      • CgA secretion was maintained by GnRH and reduced below control levels by transfer to activin only. [4]

    Induced phenotypes

    • hypogonadotropic hypogonadism
      • Hypogonadotropic hypogonadism can be caused by mutations in multiple genes, including the gonadotropin-releasing hormone receptor gene. [5]
Reference