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Details for receptor: GRP-R

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EndoNet ID: ENR00957

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Synonyms

  • gastrin-releasing peptide receptor
  • BB2
  • bombesin receptor 2
  • GRP-preferring bombesin receptor
  • GRP-R
  • GRPR

General information

  • BB2 receptor mRNA but not bombesin BB1 receptor or bombesin BB3 receptor mRNA is present in cultured human astrocytes. [1]
  • In colon GRP-receptor is expressed in the myenteric, but not submucosal, plexus as well as on smooth muscle cells. [2]
  • Highly expressed in pancreas, also expressed in stomach, adrenal cortex and brain. [3]
  • GRP-R is expressed in inhibitory interneurons of the lateral nucleus of the amygdala. [4]

Links to other resources

UniProt P30550
Ensembl ENST00000380289

Subunit information

Sequence 
MALNDCFLL NLEVDHFMH CNISSHSAD 
LPVNDDWSH PGILYVIPA VYGVIILIG 
LIGNITLIK IFCTVKSMR NVPNLFISS 
LALGDLLLL ITCAPVDAS RYLADRWLF 
GRIGCKLIP FIQLTSVGV SVFTLTALS 
ADRYKAIVR PMDIQASHA LMKICLKAA 
FIWIISMLL AIPEAVFSD LHPFHEEST 
NQTFISCAP YPHSNELHP KIHSMASFL 
VFYVIPLSI ISVYYYFIA KNLIQSAYN 
LPVEGNIHV KKQIESRKR LAKTVLVFV 
GLFAFCWLP NHVIYLYRS YHYSEVDTS 
MLHFVTSIC ARLLAFTNS CVNPFALYL 
LSKSFRKQF NTQLLCCQP GLIIRSHST 
GRSTTCMTS LKSTNPSVA TFSLINGNI 
CHERYV

Binding hormones

  • neuromedin C
  • ADM
  • GRP

Anatomical structures with this receptor

  • pancreas

    Induced phenotypes

    • positive regulation of pancreatic juice secretion
      • GRP stimulates pancreatic exocrine secretion [5]
    • regulation of epithelial cell proliferation
      • Low doses of bombesin act directly at the acinar cell or through release of non-CCK growth factors whereas high doses of bombesin act in part through CCK release. [6]
      • Bombesin stimulates the growth of normal pancreas [7]

  • stomach

    Influences

    • positive GRP
      • Stimulation of gastrin release from antral G-cells [5]

  • adrenal_cortex

  • astrocyte

  • colon

    Induced phenotypes

    • regulation of epithelial cell proliferation
      • Bombesin causes a significant growth in both the atrophic gut mucosa of rats fed an elemental diet and the injured mucosa of rats. This suggests a possible protective role for bombesin in the maintenance of gut mucosal structure after an injury that results in either atrophy or mucosal disruption. [7]
      • In adult rats, bombesin stimulates the proliferation of the colon. [8]

  • oesophagus

  • ileum

    Induced phenotypes

    • gatrointestinal motility
      • GRP modulates the gastrointestinal motility [5]

  • rectum

  • caecum

  • duodenum

  • amygdaloid_body

Reference