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Details for receptor: neuromedin B receptor

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EndoNet ID: ENR00958

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Synonyms

  • neuromedin B receptor
  • NMBR
  • bombesin 1 receptor
  • BB1

General information

  • This is a G-protein coupled receptor with seven membrane-spanning regions. [1]
  • Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. [2]
  • Bombesin-like peptide receptors are expressed in human bronchial epithelial cells. [3]

Links to other resources

UniProt P28336
Ensembl ENST00000258042

Subunit information

Neuromedin-B receptor (chain).

Sequence 
MPSKSLSNL SVTTGANES GSVPEGWER 
DFLPASDGT TTELVIRCV IPSLYLLII 
TVGLLGNIM LVKIFITNS AMRSVPNIF 
ISNLAAGDL LLLLTCVPV DASRYFFDE 
WMFGKVGCK LIPVIQLTS VGVSVFTLT 
ALSADRYRA IVNPMDMQT SGALLRTCV 
KAMGIWVVS VLLAVPEAV FSEVARISS 
LDNSSFTAC IPYPQTDEL HPKIHSVLI 
FLVYFLIPL AIISIYYYH IAKTLIKSA 
HNLPGEYNE HTKKQMETR KRLAKIVLV 
FVGCFIFCW FPNHILYMY RSFNYNEID 
PSLGHMIVT LVARVLSFG NSCVNPFAL 
YLLSESFRR HFNSQLCCG RKSYQERGT 
SYLLSSSAV RMTSLKSNA KNMVTNSVL 
LNGHSMKQE MAM
UniProt P28336

Neuromedin B receptor

Sequence 
MPSKSLSNL SVTTGANES GSVPEGWER 
DFLPASDGT TTELVIRCV IPSLYLLII 
TVGLLGNIM LVKIFITNS AMRSVPNIF 
ISNLAAGDL LLLLTCVPV DASRYFFDE 
WMFGKVGCK LIPVIQLTS VGVSVFTLT 
ALSADRYRA IVNPMDMQT SGALLRTCV 
KAMGIWVVS VLLAVPEAV FSEVARISS 
LDNSSFTAC IPYPQTDEL HPKIHSVLI 
FLVYFLIPL AIISIYYYH IAKTLIKSA 
HNLPGEYNE HTKKQMETR KRLAKIVLV 
FVGCFIFCW FPNHILYMY RSFNYNEID 
PSLGHMIVT LVARVLSFG NSCVNPFAL 
YLLSESFRR HFNSQLCCG RKSYQERGT 
SYLLSSSAV RMTSLKSNA KNMVTNSVL 
LNGHSMKQE MAM

Binding hormones

  • neuromedin B

Anatomical structures with this receptor

  • bronchial_epithelial_cell

  • digestive_system

    Induced phenotypes

    • induction of smooth muscle contraction
      • NMB and activation of NMB receptors are known to stimulate the contraction of GI smooth muscles. [4]

  • central_nerve_system_element

  • basophil_thyrotroph_cell_of_anterior_pituitary

    Influences

    • negative TSH
      • Neuromedin B acts as a constitutive autocrine TSH-release inhibitor. [5]
    • The local action is further supported by the detection of NB receptors within the gland. [5]
Reference