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Details for receptor: calcitonin-receptor-like receptor

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EndoNet ID: ENR00959

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Synonyms

  • calcitonin-receptor-like receptor
  • CALCRL
  • CRLR
  • CGRP type 1 receptor

General information

  • The lung showed intense CRLR staining over the alveolar capillaries. [1]
  • Within the digestive tract, staining was observed over the cells lining the excretory ducts of the parotid gland, over the epithelium of the fundic glands of stomach, endocrine cells of the duodenum and ileum and some myenteric ganglia. The kidney presented staining of the juxtaglomerular arteries, the glomerular capillaries and chief cells of the collecting duct. Within the endocrine organs, a strong CRLR-like immunoreactivity signal was observed over the Langerhans islets, and weak immunoreactivity in the Leydig cells of testis. [1]
  • CGRP-R, NPY-R, VIP-1R and beta2-R, but not SP-R, VIP-2R, PACAP-R, beta1-R and beta3-R, were expressed in osteoblasts as well as osteosarcoma cells. [2]
  • Immunohistochemical analysis of the cardiovascular system revealed CRLR-like immunoreactivity (CRLR-LI) in the endothelium of all blood vessels including large and small arteries, veins and capillaries, and in heart muscle cells and endocardium. [1]
  • Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. [3]

Links to other resources

UniProt Q16602
Ensembl ENST00000447403

Binding hormones

  • CGRP1
    • The calcitonin receptor-like receptor (CRLR) mediates the effects of both calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM). [1]
  • CGRP2
  • ADM2
  • ADM
    • Like CGRP, adrenomedullin’s vasodilatory effects can be inhibited by CGRP(8-37), which indicates that it too acts via the CGRP-1 receptor. [1]
    • The calcitonin receptor-like receptor (CRLR) mediates the effects of both calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM). [1]
    • Like CGRP, adrenomedullin’s vasodilatory effects can be inhibited by CGRP(8-37), which indicates that it too acts via the CGRP-1 receptor. [1]
    • Coexpression of CRLR with RAMP-1 generates a CGRP receptor, while coexpression with RAMP-2 generates an adrenomedullin receptor. [1]
  • calcitonin

Anatomical structures with this receptor

  • lung

  • blood_vessel

  • cardiac_myocyte

  • endocardium

  • juxtaglomerular_apparatus

  • mucosa_of_gastric_wall

  • Leydig_cell_of_testis

  • cell_of_adrenal_gland_zona_reticularis

  • pancreatic_islets

  • osteoblast

  • alveolar_macrophage

Reference