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Details for receptor: bradykinin receptor B2

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  • Hormones
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EndoNet ID: ENR00960

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Synonyms

  • bradykinin receptor B2
  • BDKRB2
  • bradykinin receptor 2

General information

  • Bradykinin (BK) receptors B1 (B1R) and B2 (B2R) were expressed in human osteoblasts (SaM-1) and osteosarcoma (SaOS-2, HOS, and MG-63) cells. [1]

Links to other resources

UniProt P30411
Ensembl ENST00000306005

Binding hormones

  • lysyl-bradykinin
  • bradykinin

Anatomical structures with this receptor

  • osteoblast

    Influences

    • positive interleukin 6
      • Bradykinin increased the synthesis of both IL-6 and PGE(2) and the increase in both was blocked by HOE140 (B2R antagonist). [1]
      • Bradykinin increased IL-6 and PGE2 synthesis via B2R but not B1R. [1]
    • positive PGE2
      • Bradykinin increased the synthesis of both IL-6 and PGE(2) and the increase in both was blocked by HOE140 (B2R antagonist). [1]
      • [1]
    • positive PGI2
      • The B2 receptors are linked to a burst of prostanoid release. [2]
Reference