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Details for receptor: GHSR

EndoNet ID: ENR00962

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  • GHSR
  • growth hormone secretagogue receptor

General information

Links to other resources

UniProt Q92847
Ensembl ENST00000427970

Binding hormones

  • ghrelin

Anatomical structures with this receptor

  • arcuate_nucleus_of_hypothalamus

    Induced phenotypes

    • regulation of synapse organization
      • The orexigenic hormone ghrelin has an inhibitory effect on the synaptic arrangement/rewiring of the POMC and Npy/Agrp cells in the ARC. [1]
    • positive regulation of appetite
      • Ghrelin has been shown to exert its orexigenic effect by activating NPY/Agrp neurons while inhibiting the anorexigenic POMC neurons.However, similar to leptin, ghrelin also acts in other brain regions to modulate food intake [2]
      • Ghrelin binds to neurons in the ventral tegmental area (VTA), where it increases dopamine neuronal activity and dopamine turnover in the nucleus accumbens. Direct VTA administration of ghrelin was sufficient to induce food intake, while the blockage of ghrelin's action in the VTA by infusion of a ghrelin antagonist blocked the orexigenic effect of circulating ghrelin. [3]
  • hypothalamus


    • positive GH
      • GHS-R in the hypothalamus is involved in the regulation of GH secretion, food intake, and adiposity. [4]